Literature DB >> 11440194

Coupling of nerve growth factor to its receptor: inhibition by anti-GM3 ganglioside antibody.

M Chakraborty1, D Chatterjee.   

Abstract

1. Normal differentiation of PC 12 cells and dorsal root ganglionic neurons in culture need nerve growth factor (NGF) for their neurite outgrowth. 2. An antibody against GM3 ganglioside was found to inhibit the nerve growth factor mediated neurite formation of both the cells in vitro significantly. 3. Further analysis revealed that the binding of 125I-NGF to live PC 12 cells could be markedly inhibited by anti-GM3 antibody in a dose dependent manner. 4. Scatchard analysis revealed that in the presence of anti-GM3 antibody only some low affinity binding sites were available for NGF-high affinity binding sites were totally blocked. 5. These results further strengthen the hypothesis that anti-GM3 antibody affects neuronal cell growth by interfering with the coupling of growth factors to their cell surface receptors.

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Year:  2001        PMID： 11440194     DOI： 10.1023/a:1007129514216

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  25 in total

1.  Differentiation of Neuro-2a neuroblastoma cells by an antibody to GM3 ganglioside.

Authors:  D Chatterjee; M Chakraborty; G M Anderson
Journal:  Brain Res       Date:  1992-06-26       Impact factor: 3.252

2.  Thyroidal influence on the cell surface GM1 of granule cells: its significance in cell migration during rat brain development.

Authors:  M Chakraborty; P Lahiri; D Chatterjee
Journal:  Cell Mol Neurobiol       Date:  1992-12       Impact factor: 5.046

Review 3.  Invited review: motor neuropathies, motor neuron disorders, and antiglycolipid antibodies.

Authors:  A Pestronk
Journal:  Muscle Nerve       Date:  1991-10       Impact factor: 3.217

Review 4.  Expression and possible function of nerve growth factor receptors on Schwann cells.

Authors:  E M Johnson; M Taniuchi; P S DiStefano
Journal:  Trends Neurosci       Date:  1988-07       Impact factor: 13.837

Review 5.  Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

Authors:  S Hakomori
Journal:  J Biol Chem       Date:  1990-11-05       Impact factor: 5.157

6.  Nerve growth factor determines survival and death of PC12 cells by regulation of the bcl-x, bax, and caspase-3 genes.

Authors:  P Rong; A M Bennie; W R Epa; G L Barrett
Journal:  J Neurochem       Date:  1999-06       Impact factor: 5.372

7.  A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside.

Authors:  A Pestronk; D R Cornblath; A A Ilyas; H Baba; R H Quarles; J W Griffin; K Alderson; R N Adams
Journal:  Ann Neurol       Date:  1988-07       Impact factor: 10.422

8.  Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation.

Authors:  E G Bremer; S Hakomori; D F Bowen-Pope; E Raines; R Ross
Journal:  J Biol Chem       Date:  1984-06-10       Impact factor: 5.157

9.  Lower motor neuron syndromes defined by patterns of weakness, nerve conduction abnormalities, and high titers of antiglycolipid antibodies.

Authors:  A Pestronk; V Chaudhry; E L Feldman; J W Griffin; D R Cornblath; E H Denys; M Glasberg; R W Kuncl; R K Olney; W C Yee
Journal:  Ann Neurol       Date:  1990-03       Impact factor: 10.422

10.  Ventral spinal cord inhibition of neurite outgrowth from embryonic rat dorsal root ganglia.

Authors:  M Fitzgerald; G C Kwiat; J Middleton; A Pini
Journal:  Development       Date:  1993-04       Impact factor: 6.868
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