Literature DB >> 11440079

Cytotoxic constituents of Psoralea corylifolia.

W Mar1, K H Je, E K Seo.   

Abstract

A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 microg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.

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Year:  2001        PMID： 11440079     DOI： 10.1007/BF02978259

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  12 in total

1.  Synthesis of Psoralidin derivatives and their anticancer activity: First synthesis of Lespeflorin I1.

Authors:  Pallab Pahari; Ujwal Pratim Saikia; Trinath Prasad Das; Chendil Damodaran; Jurgen Rohr
Journal:  Tetrahedron       Date:  2016-06-09       Impact factor: 2.457

2.  Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells.

Authors:  Raj Kumar; Sowmyalakshmi Srinivasan; Srinivas Koduru; Pallab Pahari; Jürgen Rohr; Natasha Kyprianou; Chendil Damodaran
Journal:  Cancer Prev Res (Phila)       Date:  2009-02-17

3.  Molecular Pathway of Psoralidin-Induced Apoptosis in HepG2 Cell Line.

Authors:  Bin Yu; An-Hong Wang; Kun Zhou; Li-Juan Chai; Lu Liu
Journal:  Chin J Integr Med       Date:  2016-03-29       Impact factor: 1.978

4.  Total synthesis of psoralidin, an anticancer natural product.

Authors:  Pallab Pahari; Jürgen Rohr
Journal:  J Org Chem       Date:  2009-04-03       Impact factor: 4.354

5.  Chloroform Extract of Rasagenthi Mezhugu, a Siddha Formulation, as an Evidence-Based Complementary and Alternative Medicine for HPV-Positive Cervical Cancers.

Authors:  Anvarbatcha Riyasdeen; Vaiyapuri S Periasamy; Preethy Paul; Ali A Alshatwi; Mohammad A Akbarsha
Journal:  Evid Based Complement Alternat Med       Date:  2011-10-27       Impact factor: 2.629

6.  Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells.

Authors:  Wenhui Hao; Xuenong Zhang; Wenwen Zhao; Xiuping Chen
Journal:  PeerJ       Date:  2014-09-09       Impact factor: 2.984

7.  Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis.

Authors:  Deeksha Pal; Suman Suman; Venkatesh Kolluru; Sophia Sears; Trinath P Das; Houda Alatassi; Murali K Ankem; Jonathan H Freedman; Chendil Damodaran
Journal:  Br J Cancer       Date:  2017-06-06       Impact factor: 7.640

8.  The coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

Authors:  Joanna Bronikowska; Ewelina Szliszka; Dagmara Jaworska; Zenon P Czuba; Wojciech Krol
Journal:  Molecules       Date:  2012-05-29       Impact factor: 4.411

9.  Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells.

Authors:  Gwang Hun Park; Ji Ho Sung; Hun Min Song; Jin Boo Jeong
Journal:  BMC Complement Altern Med       Date:  2016-09-26       Impact factor: 3.659

Review 10.  Phytochemical and Pharmacological Studies on the Genus Psoralea: A Mini Review.

Authors:  Cong-Cong Li; Teng-Long Wang; Zhong-Qun Zhang; Wen-Qiang Yang; Yue-Fei Wang; Xin Chai; Chun-Hua Wang; Zheng Li
Journal:  Evid Based Complement Alternat Med       Date:  2016-11-17       Impact factor: 2.629
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