Literature DB >> 11438663

Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase.

F M Yeong1, H H Lim, Y Wang, U Surana.   

Abstract

Periodic accumulation and destruction of mitotic cyclins are important for the initiation and termination of M phase. It is known that both APC(Cdc20) and APC(Hct1) collaborate to destroy mitotic cyclins during M phase. Here we show that this relationship between anaphase-promoting complex (APC) and Clb proteins is reversed in S phase such that the early Clb kinases (Clb3, Clb4, and Clb5 kinases) inactivate APC(Hct1) to allow Clb2 accumulation. This alternating antagonism between APC and Clb proteins during S and M phases constitutes an oscillatory system that generates undulations in the levels of mitotic cyclins.

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Year:  2001        PMID： 11438663      PMCID： PMC87233          DOI： 10.1128/MCB.21.15.5071-5081.2001

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  26 in total

1.  Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.

Authors:  W Zachariae; A Shevchenko; P D Andrews; R Ciosk; M Galova; M J Stark; M Mann; K Nasmyth
Journal:  Science       Date:  1998-02-20       Impact factor: 47.728

2.  Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28.

Authors:  H H Lim; P Y Goh; U Surana
Journal:  Mol Cell Biol       Date:  1996-11       Impact factor: 4.272

3.  Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins.

Authors:  A Amon; M Tyers; B Futcher; K Nasmyth
Journal:  Cell       Date:  1993-09-24       Impact factor: 41.582

4.  Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.

Authors:  A Amon; S Irniger; K Nasmyth
Journal:  Cell       Date:  1994-07-01       Impact factor: 41.582

5.  Yeast Hct1 is a regulator of Clb2 cyclin proteolysis.

Authors:  M Schwab; A S Lutum; W Seufert
Journal:  Cell       Date:  1997-08-22       Impact factor: 41.582

6.  CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

Authors:  R Visintin; S Prinz; A Amon
Journal:  Science       Date:  1997-10-17       Impact factor: 47.728

7.  The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae.

Authors:  U Surana; H Robitsch; C Price; T Schuster; I Fitch; A B Futcher; K Nasmyth
Journal:  Cell       Date:  1991-04-05       Impact factor: 41.582

8.  Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae.

Authors:  I Fitch; C Dahmann; U Surana; A Amon; K Nasmyth; L Goetsch; B Byers; B Futcher
Journal:  Mol Biol Cell       Date:  1992-07       Impact factor: 4.138

9.  CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.

Authors:  E Schwob; K Nasmyth
Journal:  Genes Dev       Date:  1993-07       Impact factor: 11.361

10.  Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae.

Authors:  A Yamamoto; V Guacci; D Koshland
Journal:  J Cell Biol       Date:  1996-04       Impact factor: 10.539
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  22 in total

Review 1.  Essential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit.

Authors:  Agnes L C Tan; Padmashree C G Rida; Uttam Surana
Journal:  Biochem J       Date:  2005-02-15       Impact factor: 3.857

2.  Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition.

Authors:  Amy E Ikui; Vincent Archambault; Benjamin J Drapkin; Veronica Campbell; Frederick R Cross
Journal:  Genetics       Date:  2006-12-28       Impact factor: 4.562

3.  The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle.

Authors:  Chun-Yi Cho; Christina M Kelliher; Steven B Haase
Journal:  Cell Cycle       Date:  2019-02-05       Impact factor: 4.534

4.  Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins.

Authors:  Karen Crasta; Phillips Huang; Garry Morgan; Mark Winey; Uttam Surana
Journal:  EMBO J       Date:  2006-05-11       Impact factor: 11.598

5.  Inhibition of APC-mediated proteolysis by the meiosis-specific protein kinase Ime2.

Authors:  Melanie Bolte; Patrick Steigemann; Gerhard H Braus; Stefan Irniger
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-26       Impact factor: 11.205

6.  Hyperphosphorylation of CDH1 in Glioblastoma Cancer Stem Cells Attenuates APC/CCDH1 Activity and Pharmacologic Inhibition of APC/CCDH1/CDC20 Compromises Viability.

Authors:  Kuntal De; Treg M Grubb; Abigail A Zalenski; Kayla E Pfaff; Debjani Pal; Shubhra Majumder; Matthew K Summers; Monica Venere
Journal:  Mol Cancer Res       Date:  2019-04-29       Impact factor: 5.852

7.  Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.

Authors:  Yi-Ju Lai; Feng-Ming Lin; Mei-Jen Chuang; Hui-Ju Shen; Ting-Fang Wang
Journal:  Mol Cell Biol       Date:  2010-12-20       Impact factor: 4.272

8.  Phosphorylation and dephosphorylation regulate APC/C(Cdh1) substrate degradation.

Authors:  Kobi J Simpson-Lavy; Drora Zenvirth; Michael Brandeis
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

9.  The role of Cdh1p in maintaining genomic stability in budding yeast.

Authors:  Karen E Ross; Orna Cohen-Fix
Journal:  Genetics       Date:  2003-10       Impact factor: 4.562

10.  Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin.

Authors:  Benjamin J Drapkin; Ying Lu; Andrea L Procko; Benjamin L Timney; Frederick R Cross
Journal:  Mol Syst Biol       Date:  2009-11-17       Impact factor: 11.429
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