| Literature DB >> 11438404 |
A P Verhagen1, H C de Vet, R A de Bie, M Boers, P A van den Brandt.
Abstract
The best evidence on the efficacy of medical interventions is provided by high-quality trials summarized in high-quality systematic reviews or meta-analyses. The methodological quality of studies included in a systematic review can have a substantial impact on the estimates of the treatment effect and therefore on the conclusions of such a review. But what is the empirical evidence to support quality assessment of randomized clinical trials (RCTs)? We elaborate on questions such as: what is the concept of quality of individual studies (RCTs), can quality be measured validly and reliably? Plans for future research on this issue are proposed.Mesh：
Year: 2001 PMID： 11438404 DOI： 10.1016/s0895-4356(00)00360-7
Source DB: PubMed Journal: J Clin Epidemiol ISSN： 0895-4356 Impact factor: 6.437