Literature DB >> 11434933

Expression of membrane C1q in human monocyte-derived macrophages is developmentally regulated and enhanced by interferon-gamma.

M Kaul1, M Loos.   

Abstract

The present study investigated when during "in vitro" maturation macrophages (MPhi) express membrane C1q (mC1q), and whether cell activation affects expression and function of mC1q. Although C1q mRNA was repeatedly detected in freshly isolated monocytes using reverse transcriptase-polymerase chain reaction, C1q protein was observed only in developing MPhi from day 1 to 4 on using immunodetection and flow cytometry. However, the quantity of mC1q and other MPhi membrane proteins differed strikingly in cells from different donors. We report here for the first time that CD14(+) and CD14(-) mC1q-bearing MPhi can develop, and that interferon-gamma increases mC1q display at the cell surface, and mC1q-mediated phagocytosis.

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Year:  2001        PMID： 11434933     DOI： 10.1016/s0014-5793(01)02592-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Markers of childhood lupus nephritis indicating disease activity.

Authors:  Monika Edelbauer; Sudhir Kshirsagar; Magdalena Riedl; Dieter Haffner; Heiko Billing; Burkhard Tönshoff; Sophia Ross; Jörg Dötsch; Oliver Amon; Henry Fehrenbach; Christian Steuber; Antje Beissert; Josef Hager; Gottfried Wechselberger; Lutz T Weber; Lothar Bernd Zimmerhackl
Journal:  Pediatr Nephrol       Date:  2010-12-22       Impact factor: 3.714

2.  Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium.

Authors:  Roberta Bulla; Chiara Agostinis; Fleur Bossi; Lucia Rizzi; Alessandra Debeus; Claudio Tripodo; Oriano Radillo; Francesco De Seta; Berhane Ghebrehiwet; Francesco Tedesco
Journal:  Mol Immunol       Date:  2008-03-04       Impact factor: 4.407

3.  DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.

Authors:  Kinga K Hosszu; Alisa Valentino; Uma Vinayagasundaram; Rama Vinayagasundaram; M Gordon Joyce; Yan Ji; Ellinor I B Peerschke; Berhane Ghebrehiwet
Journal:  Blood       Date:  2012-06-13       Impact factor: 22.113

4.  Reduced expression of C1q-mRNA in monocytes from patients with systemic lupus erythematosus.

Authors:  F Moosig; F Damm; A Knorr-Spahr; M Ritgen; R A Zeuner; M Kneba; M Ernst; J O Schröder
Journal:  Clin Exp Immunol       Date:  2006-12       Impact factor: 4.330

5.  Evidence that a C1q/C1qR system regulates monocyte-derived dendritic cell differentiation at the interface of innate and acquired immunity.

Authors:  Kinga K Hosszu; Frances Santiago-Schwarz; Ellinor I B Peerschke; Berhane Ghebrehiwet
Journal:  Innate Immun       Date:  2009-08-26       Impact factor: 2.680

6.  Interferon-gamma reduces cell surface expression of annexin 2 and suppresses the invasive capacity of prostate cancer cells.

Authors:  Claire Hastie; John R Masters; Stephen E Moss; Soren Naaby-Hansen
Journal:  J Biol Chem       Date:  2008-01-22       Impact factor: 5.157

7.  C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition.

Authors:  Helena Païdassi; Pascale Tacnet-Delorme; Virginie Garlatti; Claudine Darnault; Berhane Ghebrehiwet; Christine Gaboriaud; Gérard J Arlaud; Philippe Frachet
Journal:  J Immunol       Date:  2008-02-15       Impact factor: 5.422

8.  Cell surface expression and function of the macromolecular c1 complex on the surface of human monocytes.

Authors:  Kinga K Hosszu; Alisa Valentino; Yan Ji; Mara Matkovic; Lina Pednekar; Nina Rehage; Nithin Tumma; Ellinor I B Peerschke; Berhane Ghebrehiwet
Journal:  Front Immunol       Date:  2012-03-05       Impact factor: 7.561

Review 9.  Monocyte Expressed Macromolecular C1 and C1q Receptors as Molecular Sensors of Danger: Implications in SLE.

Authors:  Berhane Ghebrehiwet; Kinga K Hosszu; Alisa Valentino; Yan Ji; Ellinor I B Peerschke
Journal:  Front Immunol       Date:  2014-06-26       Impact factor: 7.561

10.  Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies.

Authors:  M Sips; M Krykbaeva; T J Diefenbach; M Ghebremichael; B A Bowman; A-S Dugast; A W Boesch; H Streeck; D S Kwon; M E Ackerman; T J Suscovich; P Brouckaert; T W Schacker; G Alter
Journal:  Mucosal Immunol       Date:  2016-02-17       Impact factor: 7.313
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