Literature DB >> 11434920

Alterations in expression of E2F-1 and E2F-responsive genes by RB, p53 and p21(Sdi1/WAF1/Cip1) expression.

K Ookawa1, S Tsuchida, T Kohno, J Yokota.   

Abstract

RB, p53 and p21(Sdi1/WAF1/Cip1) interact in the induction of G1 arrest. We established osteosarcoma cell lines in which a tetracycline-regulatable promoter controls the induction of RB, p53 and p21. By using these cell lines, we investigated whether RB, p53 or p21 regulates, in the same manner or differently, expression and function of E2F-1 and its responsive genes. E2F-1 gene products and transcripts of the E2F-responsive genes decreased in response to RB. Similar changes occurred to p53 and p21 when RB is present. However, in the absence of RB, some of the E2F-responsive genes decreased in response to p53 but not to p21. Thus, RB is a critical component for regulating the E2F-responsive genes, while p53 alone affects only a subset of these genes.

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Year:  2001        PMID： 11434920     DOI： 10.1016/s0014-5793(01)02583-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation.

Authors:  Chiharu Uchida; Seiichi Miwa; Kyoko Kitagawa; Takayuki Hattori; Tomoyasu Isobe; Sunao Otani; Toshiaki Oda; Haruhiko Sugimura; Takehiko Kamijo; Keizou Ookawa; Hideyo Yasuda; Masatoshi Kitagawa
Journal:  EMBO J       Date:  2004-12-02       Impact factor: 11.598

2.  Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.

Authors:  Yasumichi Inoue; Masatoshi Kitagawa; Yoichi Taya
Journal:  EMBO J       Date:  2007-03-22       Impact factor: 11.598

3.  Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy.

Authors:  Zhuo Zhang; Mao Li; Hui Wang; Sudhir Agrawal; Ruiwen Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-16       Impact factor: 11.205

4.  E2F4 Promotes Neuronal Regeneration and Functional Recovery after Spinal Cord Injury in Zebrafish.

Authors:  Shota Sasagawa; Yuhei Nishimura; Yuka Hayakawa; Soichiro Murakami; Yoshifumi Ashikawa; Mizuki Yuge; Shiko Okabe; Koki Kawaguchi; Reiko Kawase; Toshio Tanaka
Journal:  Front Pharmacol       Date:  2016-05-09       Impact factor: 5.810

5.  p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.

Authors:  Ran Brosh; Reut Shalgi; Atar Liran; Gilad Landan; Katya Korotayev; Giang Huong Nguyen; Espen Enerly; Hilde Johnsen; Yosef Buganim; Hilla Solomon; Ido Goldstein; Shalom Madar; Naomi Goldfinger; Anne-Lise Børresen-Dale; Doron Ginsberg; Curtis C Harris; Yitzhak Pilpel; Moshe Oren; Varda Rotter
Journal:  Mol Syst Biol       Date:  2008-11-25       Impact factor: 11.429

6.  Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.

Authors:  Alan E Bilsland; Katrina Stevenson; Yu Liu; Stacey Hoare; Claire J Cairney; Jon Roffey; W Nicol Keith
Journal:  PLoS Comput Biol       Date:  2014-02-13       Impact factor: 4.475
  6 in total

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