OBJECTIVE: This study investigated the relationship between outcome and structural brain abnormalities in schizophrenia. METHOD: Intracranial volume and volumes of the cerebrum, gray and white matter, lateral and third ventricles, frontal lobes, thalamus, and cerebellum were measured in 20 patients with a poor outcome, 25 with a favorable outcome, and 23 healthy comparison subjects with magnetic resonance imaging. RESULTS: Thalamic volume was significantly smaller both in poor-outcome patients and good-outcome patients. In contrast, only poor-outcome patients displayed significantly smaller cerebral gray matter, particularly prefrontal, and enlargement of the lateral and third ventricles. No significant differences were found for intracranial, cerebellar, or cortical CSF volumes. CONCLUSIONS: Smaller thalamic volumes in schizophrenia may reflect a greater susceptibility for the disorder and seem unrelated to outcome. In contrast, gray matter volume loss of the cerebrum, particularly in the frontal lobes, and lateral and third ventricular enlargement appear related to outcome in schizophrenia.
OBJECTIVE: This study investigated the relationship between outcome and structural brain abnormalities in schizophrenia. METHOD: Intracranial volume and volumes of the cerebrum, gray and white matter, lateral and third ventricles, frontal lobes, thalamus, and cerebellum were measured in 20 patients with a poor outcome, 25 with a favorable outcome, and 23 healthy comparison subjects with magnetic resonance imaging. RESULTS: Thalamic volume was significantly smaller both in poor-outcome patients and good-outcome patients. In contrast, only poor-outcome patients displayed significantly smaller cerebral gray matter, particularly prefrontal, and enlargement of the lateral and third ventricles. No significant differences were found for intracranial, cerebellar, or cortical CSF volumes. CONCLUSIONS: Smaller thalamic volumes in schizophrenia may reflect a greater susceptibility for the disorder and seem unrelated to outcome. In contrast, gray matter volume loss of the cerebrum, particularly in the frontal lobes, and lateral and third ventricular enlargement appear related to outcome in schizophrenia.
Authors: C Laidi; M-A d'Albis; M Wessa; J Linke; M L Phillips; M Delavest; F Bellivier; A Versace; J Almeida; S Sarrazin; C Poupon; K Le Dudal; C Daban; N Hamdani; M Leboyer; J Houenou Journal: Acta Psychiatr Scand Date: 2014-11-28 Impact factor: 6.392
Authors: T Moberget; N T Doan; D Alnæs; T Kaufmann; A Córdova-Palomera; T V Lagerberg; J Diedrichsen; E Schwarz; M Zink; S Eisenacher; P Kirsch; E G Jönsson; H Fatouros-Bergman; L Flyckt; G Pergola; T Quarto; A Bertolino; D Barch; A Meyer-Lindenberg; I Agartz; O A Andreassen; L T Westlye Journal: Mol Psychiatry Date: 2017-05-16 Impact factor: 15.992
Authors: Denise M Coscia; Katherine L Narr; Delbert G Robinson; Liberty S Hamilton; Serge Sevy; Katherine E Burdick; Handan Gunduz-Bruce; Joanne McCormack; Robert M Bilder; Philip R Szeszko Journal: Hum Brain Mapp Date: 2009-04 Impact factor: 5.038
Authors: Qi Li; Charlton Cheung; Ran Wei; Edward S Hui; Joram Feldon; Urs Meyer; Sookja Chung; Siew E Chua; Pak C Sham; Ed X Wu; Grainne M McAlonan Journal: PLoS One Date: 2009-07-24 Impact factor: 3.240