Literature DB >> 11431029

Towards a pharmacology of DNA methylation.

M Szyf1.   

Abstract

DNA methylation plays an important role in controlling gene-expression programs. Increasing evidence indicates that the enzyme responsible for replicating the DNA methylation pattern, DNA methyltransferase 1 (DNMT1), has a role in cancer. In this article, it is suggested that DNMT1 is a multifunctional protein that has regulatory activities in addition to DNA methylation activity. These functions are assembled into one protein to ensure the coordinate replication of DNA and its methylation pattern. The regulatory activities of DNMT1 are proposed to be involved in cellular transformation and should, therefore, serve as the targets for novel anti-cancer agents.

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Year:  2001        PMID： 11431029     DOI： 10.1016/s0165-6147(00)01713-2

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  14 in total

1.  The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides.

Authors:  Juliet M Daniel; Christopher M Spring; Howard C Crawford; Albert B Reynolds; Akeel Baig
Journal:  Nucleic Acids Res       Date:  2002-07-01       Impact factor: 16.971

Review 2.  Child health, developmental plasticity, and epigenetic programming.

Authors:  Z Hochberg; R Feil; M Constancia; M Fraga; C Junien; J-C Carel; P Boileau; Y Le Bouc; C L Deal; K Lillycrop; R Scharfmann; A Sheppard; M Skinner; M Szyf; R A Waterland; D J Waxman; E Whitelaw; K Ong; K Albertsson-Wikland
Journal:  Endocr Rev       Date:  2010-10-22       Impact factor: 19.871

3.  Ubiquitination/deubiquitination and acetylation/deacetylation: making DNMT1 stability more coordinated.

Authors:  Qi Hong; Zhi-ming Shao
Journal:  Acta Pharmacol Sin       Date:  2011-02       Impact factor: 6.150

4.  Epigenetics, behaviour, and health.

Authors:  Moshe Szyf; Michael J Meaney
Journal:  Allergy Asthma Clin Immunol       Date:  2008-03-15       Impact factor: 3.406

Review 5.  Diet and the epigenetic (re)programming of phenotypic differences in behavior.

Authors:  Patrick O McGowan; Michael J Meaney; Moshe Szyf
Journal:  Brain Res       Date:  2008-07-29       Impact factor: 3.252

6.  An engineered split M.HhaI-zinc finger fusion lacks the intended methyltransferase specificity.

Authors:  Glenna E Meister; Srinivasan Chandrasegaran; Marc Ostermeier
Journal:  Biochem Biophys Res Commun       Date:  2008-10-01       Impact factor: 3.575

7.  On the epigenetic regulation of the human reelin promoter.

Authors:  Ying Chen; Rajiv P Sharma; Robert H Costa; Erminio Costa; Dennis R Grayson
Journal:  Nucleic Acids Res       Date:  2002-07-01       Impact factor: 16.971

8.  Schizophrenia: redox regulation and volume neurotransmission.

Authors:  I Bókkon; I Antal
Journal:  Curr Neuropharmacol       Date:  2011-06       Impact factor: 7.363

Review 9.  Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.

Authors:  Michael J Meaney; Moshe Szyf
Journal:  Dialogues Clin Neurosci       Date:  2005       Impact factor: 5.986

10.  Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo.

Authors:  Bushra Ateeq; Alexander Unterberger; Moshe Szyf; Shafaat A Rabbani
Journal:  Neoplasia       Date:  2008-03       Impact factor: 5.715
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