Literature DB >> 11430794

Metal chelator decreases Alzheimer beta-amyloid plaques.

G K Gouras1, M F Beal.   

Abstract

Transgenic mice developing beta-amyloid (Abeta) plaques are advancing experimental treatment strategies for Alzheimer's disease. The metal chelator, clioquinol, is reported by Cherny et al. (2001) to reduce Abeta plaques, presumably by chelation of Abeta-associated zinc and copper. This and other recent Abeta-modulating treatment approaches are discussed.

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Year:  2001        PMID： 11430794     DOI： 10.1016/s0896-6273(01)00330-0

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  8 in total

1.  A cell-based phenotypic assay to identify cardioprotective agents.

Authors:  Stephanie Guo; Adam Olm-Shipman; Andrew Walters; William R Urciuoli; Stefanie Devito; Sergiy M Nadtochiy; Andrew P Wojtovich; Paul S Brookes
Journal:  Circ Res       Date:  2012-03-06       Impact factor: 17.367

Review 2.  Challenges associated with metal chelation therapy in Alzheimer's disease.

Authors:  Muralidhar L Hegde; P Bharathi; Anitha Suram; Chitra Venugopal; Ramya Jagannathan; Pankaj Poddar; Pullabhatla Srinivas; Kumar Sambamurti; Kosagisharaf Jagannatha Rao; Janez Scancar; Luigi Messori; Luigi Zecca; Paolo Zatta
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

Review 3.  Therapeutic targets of brain insulin resistance in sporadic Alzheimer's disease.

Authors:  Suzanne M de la Monte
Journal:  Front Biosci (Elite Ed)       Date:  2012-01-01

Review 4.  Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease.

Authors:  Suzanne M de la Monte
Journal:  Curr Alzheimer Res       Date:  2012-01       Impact factor: 3.498

Review 5.  The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease.

Authors:  Simon C Drew
Journal:  Front Neurosci       Date:  2017-06-02       Impact factor: 4.677

Review 6.  Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease.

Authors:  Bruno Fonseca-Santos; Maria Palmira Daflon Gremião; Marlus Chorilli
Journal:  Int J Nanomedicine       Date:  2015-08-04

Review 7.  The Therapeutic Potential of Rosemary (Rosmarinus officinalis) Diterpenes for Alzheimer's Disease.

Authors:  Solomon Habtemariam
Journal:  Evid Based Complement Alternat Med       Date:  2016-01-28       Impact factor: 2.629

8.  Changes in intracellular copper concentration and copper-regulating gene expression after PC12 differentiation into neurons.

Authors:  Yasumitsu Ogra; Aya Tejima; Naohiro Hatakeyama; Moeko Shiraiwa; Siyuan Wu; Tsutomu Ishikawa; Ayako Yawata; Yasumi Anan; Noriyuki Suzuki
Journal:  Sci Rep       Date:  2016-09-13       Impact factor: 4.379
  8 in total

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