Literature DB >> 11430053

Synthesis of 5'-deoxy-5'-thioguanosine-5'-monophosphorothioate and its incorporation into RNA 5'-termini.

B Zhang1, Z Cui, L Sun.   

Abstract

[figure: see text] 5'-Deoxy-5'-thioguanosine-5'-monophosphorothioate (GSMP) was synthesized in four steps with 35% overall yield. GSMP serves as a good substrate for in vitro transcription with T7 RNA polymerase to yield 5'-GSMP-RNA, which was converted to 5'-HS-RNA by dephosphorylation with alkaline phosphatase. The thiol-reactive agents can be efficiently introduced into the 5'-terminus of RNA.

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Year:  2001        PMID： 11430053     DOI： 10.1021/ol006916s

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

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2.  Synthesis of adenosine derivatives as transcription initiators and preparation of 5' fluorescein- and biotin-labeled RNA through one-step in vitro transcription.

Authors:  Faqing Huang; Guocan Wang; Tricia Coleman; Na Li
Journal:  RNA       Date:  2003-12       Impact factor: 4.942

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Authors:  Nan-Sheng Li; John K Frederiksen; Selene C Koo; Jun Lu; Timothy J Wilson; David M J Lilley; Joseph A Piccirilli
Journal:  Nucleic Acids Res       Date:  2010-12-09       Impact factor: 16.971

4.  Corroboration of Zn(ii)-Mg(ii)-tertiary structure interplays essential for the optimal catalysis of a phosphorothiolate thiolesterase ribozyme.

Authors:  Tzu-Pin Wang; Yu-Chih Su; Yi Chen; Scott Severance; Chi-Ching Hwang; Yi-Ming Liou; Chia-Hui Lu; Kun-Liang Lin; Rui Jing Zhu; Eng-Chi Wang
Journal:  RSC Adv       Date:  2018-09-21       Impact factor: 3.361

5.  Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.

Authors:  Fadi Soukarieh; Matthew W Nowicki; Amandine Bastide; Tuija Pöyry; Carolyn Jones; Kate Dudek; Geetanjali Patwardhan; François Meullenet; Neil J Oldham; Malcolm D Walkinshaw; Anne E Willis; Peter M Fischer
Journal:  Eur J Med Chem       Date:  2016-08-24       Impact factor: 6.514

6.  Co-existence of Distinct Supramolecular Assemblies in Solution and in the Solid State.

Authors:  G N Manjunatha Reddy; Aida Huqi; Dinu Iuga; Satoshi Sakurai; Andrew Marsh; Jeffery T Davis; Stefano Masiero; Steven P Brown
Journal:  Chemistry       Date:  2016-12-22       Impact factor: 5.236

7.  5'-deoxy-5'-hydrazinylguanosine as an initiator of T7 Rna polymerase-catalyzed transcriptions for the preparation of labeling-ready RNAs.

Authors:  Mark Skipsey; Gordon Hack; Thomas A Hooper; Mark C Shankey; Louis P Conway; Martin Schröder; David R W Hodgson
Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2013       Impact factor: 1.381
  7 in total

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