Literature DB >> 11428545

The amyloid-beta peptide and its role in Alzheimer's disease.

A B Clippingdale1, J D Wade, C J Barrow.   

Abstract

Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid-beta (A beta) peptide, which is currently the subject of intense study. This review discusses some recent studies in the area of A beta synthesis, purification and structural analysis. Also discussed are proposed mechanisms for A beta-induced neurotoxicity and some recent advances in the development of A beta-related therapeutic strategies.

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Year:  2001        PMID： 11428545     DOI： 10.1002/psc.324

Source DB:  PubMed          Journal:  J Pept Sci        ISSN： 1075-2617            Impact factor:   1.905


  16 in total

1.  Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains.

Authors:  A Kodam; M Maulik; K Peake; A Amritraj; K S Vetrivel; G Thinakaran; J E Vance; S Kar
Journal:  Glia       Date:  2010-08-15       Impact factor: 7.452

2.  The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.

Authors:  Annamaria Lanzillotta; Ilenia Sarnico; Marina Benarese; Caterina Branca; Cristina Baiguera; Birgit Hutter-Paier; Manfred Windisch; Pierfranco Spano; Bruno Pietro Imbimbo; Marina Pizzi
Journal:  J Mol Neurosci       Date:  2010-12-22       Impact factor: 3.444

3.  Recognition of conformational changes in beta-lactoglobulin by molecularly imprinted thin films.

Authors:  Nicholas W Turner; Xiao Liu; Sergey A Piletsky; Vladimir Hlady; David W Britt
Journal:  Biomacromolecules       Date:  2007-08-01       Impact factor: 6.988

4.  A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease.

Authors:  Angela Fortner McKoy; Jermont Chen; Trudi Schupbach; Michael H Hecht
Journal:  J Biol Chem       Date:  2012-09-19       Impact factor: 5.157

5.  Structure-activity relationships for a series of compounds that inhibit aggregation of the Alzheimer's peptide, Aβ42.

Authors:  Angela F McKoy; Jermont Chen; Trudi Schupbach; Michael H Hecht
Journal:  Chem Biol Drug Des       Date:  2014-05-21       Impact factor: 2.817

6.  Efficient implementation of constant pH molecular dynamics on modern graphics processors.

Authors:  Evan J Arthur; Charles L Brooks
Journal:  J Comput Chem       Date:  2016-07-12       Impact factor: 3.376

7.  Noncovalent interaction between amyloid-beta-peptide (1-40) and oleuropein studied by electrospray ionization mass spectrometry.

Authors:  Fotini N Bazoti; Jonas Bergquist; Karin E Markides; Anthony Tsarbopoulos
Journal:  J Am Soc Mass Spectrom       Date:  2006-02-28       Impact factor: 3.109

8.  Constant pH molecular dynamics with proton tautomerism.

Authors:  Jana Khandogin; Charles L Brooks
Journal:  Biophys J       Date:  2005-04-29       Impact factor: 4.033

9.  Interaction between amyloid-β peptide and heme probed by electrochemistry and atomic force microscopy.

Authors:  Yanli Zhou; Jing Wang; Lantao Liu; Rongrong Wang; Xinhe Lai; Maotian Xu
Journal:  ACS Chem Neurosci       Date:  2013-01-24       Impact factor: 4.418

Review 10.  Role of cholesterol in APP metabolism and its significance in Alzheimer's disease pathogenesis.

Authors:  M Maulik; D Westaway; J H Jhamandas; S Kar
Journal:  Mol Neurobiol       Date:  2012-09-16       Impact factor: 5.590
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