Literature DB >> 11427529

The interaction of DNA mismatch repair proteins with human exonuclease I.

C Schmutte1, M M Sadoff, K S Shim, S Acharya, R Fishel.   

Abstract

Exonucleolytic degradation of DNA is an essential part of many DNA metabolic processes including DNA mismatch repair (MMR) and recombination. Human exonuclease I (hExoI) is a member of a family of conserved 5' --> 3' exonucleases, which are implicated in these processes by genetic studies. Here, we demonstrate that hExoI binds strongly to hMLH1, and we describe interaction regions between hExoI and the MMR proteins hMSH2, hMSH3, and hMLH1. In addition, hExoI forms an immunoprecipitable complex with hMLH1/hPMS2 in vivo. The study of interaction regions suggests a biochemical mechanism of the involvement of hExoI as a downstream effector in MMR and/or DNA recombination.

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Year:  2001        PMID： 11427529     DOI： 10.1074/jbc.M102670200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  58 in total

1.  Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A.

Authors:  Cecilia Ramilo; Liya Gu; Shuangli Guo; Xiping Zhang; Steve M Patrick; John J Turchi; Guo-Min Li
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

Review 2.  Mismatch repair.

Authors:  Richard Fishel
Journal:  J Biol Chem       Date:  2015-09-09       Impact factor: 5.157

3.  hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair.

Authors:  Anthony T Vo; Fengxue Zhu; Xiling Wu; Fenghua Yuan; Yin Gao; Liya Gu; Guo-Min Li; Tai-Hsien Lee; Chengtao Her
Journal:  EMBO Rep       Date:  2005-05       Impact factor: 8.807

4.  Functional interrogation of Lynch syndrome-associated MSH2 missense variants via CRISPR-Cas9 gene editing in human embryonic stem cells.

Authors:  Abhijit Rath; Akriti Mishra; Victoria Duque Ferreira; Chaoran Hu; Gregory Omerza; Kevin Kelly; Andrew Hesse; Honey V Reddi; James P Grady; Christopher D Heinen
Journal:  Hum Mutat       Date:  2019-08-17       Impact factor: 4.878

5.  EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells.

Authors:  Chun-Chin Chen; Elena Avdievich; Yongwei Zhang; Yu Zhang; Kaichun Wei; Kyeryoung Lee; Winfried Edelmann; Maria Jasin; Jeannine R LaRocque
Journal:  DNA Repair (Amst)       Date:  2017-07-10

6.  Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.

Authors:  Jillian Orans; Elizabeth A McSweeney; Ravi R Iyer; Michael A Hast; Homme W Hellinga; Paul Modrich; Lorena S Beese
Journal:  Cell       Date:  2011-04-15       Impact factor: 41.582

7.  hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery.

Authors:  Timothy Snowden; Kang-Sup Shim; Christoph Schmutte; Samir Acharya; Richard Fishel
Journal:  J Biol Chem       Date:  2007-10-30       Impact factor: 5.157

8.  Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer.

Authors:  Xiaoqun Dong; Li Jiao; Yanan Li; Douglas B Evans; Huamin Wang; Kenneth R Hess; James L Abbruzzese; Donghui Li
Journal:  J Clin Oncol       Date:  2009-02-23       Impact factor: 44.544

Review 9.  DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets.

Authors:  Long Shan Li; Julio C Morales; Martina Veigl; David Sedwick; Sheldon Greer; Mark Meyers; Mark Wagner; Richard Fishel; David A Boothman
Journal:  Br J Pharmacol       Date:  2009-09-23       Impact factor: 8.739

10.  Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants.

Authors:  Hellen Houlleberghs; Marleen Dekker; Hildo Lantermans; Roos Kleinendorst; Hendrikus Jan Dubbink; Robert M W Hofstra; Senno Verhoef; Hein Te Riele
Journal:  Proc Natl Acad Sci U S A       Date:  2016-03-07       Impact factor: 11.205
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