A classical inactivated vaccine induces protection against caprine herpesvirus 1 infection in goats.

Eight goats were inoculated with an inactivated caprine herpesvirus 1 (CpHV-1) vaccine. Four unvaccinated goats were kept as controls. After 30 days, four of the eight goats were revaccinated. Fifty days after the first vaccination the animals were divided into two groups (A and B) of six goats each (two goats vaccinated twice, two goats vaccinated once and two goats unvaccinated). The two groups were challenged with CpHV-1 intranasally (group A) or intravaginally (group B). After CpHV-1 challenge, the four control goats showed the typical genital lesions, whereas all the vaccinated goats were fully protected against clinical signs. Protection against infection depended on the number of injections of vaccine and the route of challenge.