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Literature DB >> 11426651

Potential roles of antisense technology in cancer chemotherapy.

Abstract

Antisense technology may play a major role in cancer chemotherapy. It is clearly a tool of exceptional value in the functionalization of genes and their validation as potential targets for cancer chemotherapy. Additionally, there is now substantial evidence that antisense drugs are safe, and a growing body of data showing activity in animal models of human disease including cancer, and suggesting efficacy in patients with cancer. In this article, I review the progress in the technology, the anticancer antisense drugs in development and potential roles that antisense technology might play.

Entities: Disease Species

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Year: 2000 PMID： 11426651 DOI： 10.1038/sj.onc.1204093

Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867

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Cited

9 in total

1. Effects of phosphorothioate anti-sense oligodeoxynucleotides on colorectal cancer cell growth and telomerase activity.

Authors: Xi-Shan Wang; Kuan Wang; Xue Li; Song-Bin Fu
Journal: World J Gastroenterol Date: 2004-12-01 Impact factor: 5.742

2. Inhibitory effect of tissue transglutaminase (tTG) antisense oligodeoxynucleotides on tTG expression in cultured bovine trabecular meshwork cells.

Authors: Yizhen Hu; Haijiang Zhang; Xinchun Xiong; Yang Cao; Yongjuan Han; Zulian Xi
Journal: J Huazhong Univ Sci Technolog Med Sci Date: 2005

3. Antisense oligonucleotide mediated knockdown of HOXC13 affects cell growth and induces apoptosis in tumor cells and over expression of HOXC13 induces 3D-colony formation.

Authors: Sahba Kasiri; Khairul I Ansari; Imran Hussain; Arunoday Bhan; Subhrangsu S Mandal
Journal: RSC Adv Date: 2012-12-18 Impact factor: 3.361

Review 4. Antisense, RNAi, and gene silencing strategies for therapy: mission possible or impossible?

Authors: Elizabeth R Rayburn; Ruiwen Zhang
Journal: Drug Discov Today Date: 2008-05-03 Impact factor: 7.851

5. Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy.

Authors: Zhuo Zhang; Mao Li; Hui Wang; Sudhir Agrawal; Ruiwen Zhang
Journal: Proc Natl Acad Sci U S A Date: 2003-09-16 Impact factor: 11.205

Potential roles of antisense technology in cancer chemotherapy.

1. Effects of phosphorothioate anti-sense oligodeoxynucleotides on colorectal cancer cell growth and telomerase activity.

2. Inhibitory effect of tissue transglutaminase (tTG) antisense oligodeoxynucleotides on tTG expression in cultured bovine trabecular meshwork cells.

3. Antisense oligonucleotide mediated knockdown of HOXC13 affects cell growth and induces apoptosis in tumor cells and over expression of HOXC13 induces 3D-colony formation.

Review 4. Antisense, RNAi, and gene silencing strategies for therapy: mission possible or impossible?

5. Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy.

6. Meta-analysis of efficacy and safety of custirsen in patients with metastatic castration-resistant prostate cancer.

7. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome.

8. Lack of correlation between MYCN expression and the Warburg effect in neuroblastoma cell lines.

9. Synthesis and evaluation of L-arabinose-based cationic glycolipids as effective vectors for pDNA and siRNA in vitro.