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Literature DB >> 11426230

A neural circuit for circadian regulation of arousal.

G Aston-Jones¹, S Chen, Y Zhu, M L Oshinsky.

Abstract

An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indirect projection from the SCN to the noradrenergic nucleus locus coeruleus (LC), a brain arousal system. Double-labeling experiments revealed several possible links between the SCN and the LC, including the dorsomedial (DMH) and paraventricular hypothalamic nuclei (PVN), as well as medial and ventrolateral pre-optic areas. Lesion studies confirmed that the DMH is a substantial relay in this circuit. Next, neurophysiology experiments revealed circadian variations in LC impulse activity. Lesions of the DMH eliminated these circadian changes in LC activity, confirming the functionality of the SCN-DMH-LC circuit. These results reveal mechanisms for regulation of circadian and sleep-waking functions.

Entities: Disease Gene

Mesh：

Year: 2001 PMID： 11426230 DOI： 10.1038/89522

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

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Cited

174 in total

1. Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits.

Authors: Gary E Pickard; Cynthia A Smeraski; Christine C Tomlinson; Bruce W Banfield; Jessica Kaufman; Christine L Wilcox; Lynn W Enquist; Patricia J Sollars
Journal: J Neurosci Date: 2002-04-01 Impact factor: 6.167

2. The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.

Authors: Julia Z Solarewicz; Mariana Angoa-Perez; Donald M Kuhn; Jason H Mateika
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2014-11-12 Impact factor: 3.619

A neural circuit for circadian regulation of arousal.

1. Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits.

2. The sleep-wake cycle and motor activity, but not temperature, are disrupted over the light-dark cycle in mice genetically depleted of serotonin.

3. Interactions between focused synaptic inputs and diffuse neuromodulation in the spinal cord.

Review 4. Sleep and circadian rhythms: do sleep centers talk back to the clock?

5. The influence of spike rate and stimulus duration on noradrenergic neurons.

6. 3-Monoiodothyronamine: the rationale for its action as an endogenous adrenergic-blocking neuromodulator.

7. Motor unit discharge rates of the anconeus muscle during high-velocity elbow extensions.

Review 8. Sleep in older adults and in subjects with dementia.

9. Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons.

Review 10. Sex differences in circadian timing systems: implications for disease.