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Literature DB >> 11425949

Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD.

Abstract

The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor fluctuations in PD.

Entities: Disease Gene

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Year: 2001 PMID： 11425949 DOI： 10.1212/wnl.56.12.1757

Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910

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Cited

20 in total

1. Antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia: associations with dopamine and serotonin receptor and transporter polymorphisms.

Authors: Cüneyt Güzey; Maria Gabriella Scordo; Edoardo Spina; Veslemøy Malm Landsem; Olav Spigset
Journal: Eur J Clin Pharmacol Date: 2007-01-17 Impact factor: 2.953

Review 2. Genetics and Treatment Response in Parkinson's Disease: An Update on Pharmacogenetic Studies.

Authors: Cristina Politi; Cinzia Ciccacci; Giuseppe Novelli; Paola Borgiani
Journal: Neuromolecular Med Date: 2018-01-05 Impact factor: 3.843

Review 3. Dopamine dysregulation syndrome: an overview of its epidemiology, mechanisms and management.

Authors: Sean S O'Sullivan; Andrew H Evans; Andrew J Lees
Journal: CNS Drugs Date: 2009 Impact factor: 5.749

4. Fast-scan cyclic voltammetry demonstrates that L-DOPA produces dose-dependent, regionally selective bimodal effects on striatal dopamine kinetics in vivo.

Authors: Rashed Harun; Kristin M Hare; Elizabeth M Brough; Miranda J Munoz; Christine M Grassi; Gonzalo E Torres; Anthony A Grace; Amy K Wagner
Journal: J Neurochem Date: 2016-01-13 Impact factor: 5.372

5. Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinson's disease.

Authors: Maurits E L Arbouw; Kris L L Movig; Toine C G Egberts; Petra J E Poels; Jeroen P P van Vugt; Judith A M Wessels; R J H M van der Straaten; Cees Neef; Henk-Jan Guchelaar
Journal: Eur J Clin Pharmacol Date: 2009-12 Impact factor: 2.953

Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD.

1. Antipsychotic-induced extrapyramidal symptoms in patients with schizophrenia: associations with dopamine and serotonin receptor and transporter polymorphisms.

Review 2. Genetics and Treatment Response in Parkinson's Disease: An Update on Pharmacogenetic Studies.

Review 3. Dopamine dysregulation syndrome: an overview of its epidemiology, mechanisms and management.

4. Fast-scan cyclic voltammetry demonstrates that L-DOPA produces dose-dependent, regionally selective bimodal effects on striatal dopamine kinetics in vivo.

5. Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinson's disease.

6. Association of the DRD2 and DRD3 polymorphisms with response to pramipexole in Parkinson's disease patients.

7. Increased intravenous morphine self-administration following Roux-en-Y gastric bypass in dietary obese rats.

8. Variants in GBA, SNCA, and MAPT influence Parkinson disease risk, age at onset, and progression.

9. Dopamine receptors and BDNF-haplotypes predict dyskinesia in Parkinson's disease.

10. A Nested Allele-Specific Multiplex Polymerase Chain Reaction Method for the Detection of DRD2 Polymorphisms.