| Literature DB >> 11425553 |
I O Donkor1, X Zheng, J Han, C Lacy, D D Miller.
Abstract
alpha-Ketohydroxamates were synthesized as bioisosteres of alpha-ketoamides. The alpha-ketohydroxamates were generally more potent than the corresponding alpha-ketoamides. The potency of the compounds suggests that hydrogen bonding and steric bulk of substituents on the nitrogen atom of the ketoamide moiety influence calpain inhibition.Entities:
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Year: 2001 PMID： 11425553 DOI： 10.1016/s0960-894x(01)00301-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823