Literature DB >> 11425536

Ethambutol analogues as potential antimycobacterial agents.

H Häusler1, R P Kawakami, E Mlaker, W B Severn, A E Stütz.   

Abstract

A range of new ethambutol analogues was synthesised and their inhibitory potencies were probed with Mycobacterium smegmatis. Interestingly, apparently even minor deviation from the structure of the parent compound resulted in reduced antimycobacterial activity.

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Year:  2001        PMID: 11425536     DOI: 10.1016/s0960-894x(01)00258-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  4 in total

1.  Ester-prodrugs of ethambutol control its antibacterial activity and provide rapid screening for mycobacterial hydrolase activity.

Authors:  Erik M Larsen; Dominique C Stephens; Nathan H Clarke; R Jeremy Johnson
Journal:  Bioorg Med Chem Lett       Date:  2017-08-30       Impact factor: 2.823

2.  Design, synthesis, and evaluation of novel ethambutol analogues.

Authors:  Raghunandan Yendapally; Richard E Lee
Journal:  Bioorg Med Chem Lett       Date:  2008-01-19       Impact factor: 2.823

Review 3.  Microbial esterases and ester prodrugs: An unlikely marriage for combating antibiotic resistance.

Authors:  Erik M Larsen; R Jeremy Johnson
Journal:  Drug Dev Res       Date:  2018-10-10       Impact factor: 4.360

4.  Production of (S)-2-aminobutyric acid and (S)-2-aminobutanol in Saccharomyces cerevisiae.

Authors:  Nora Weber; Anaëlle Hatsch; Ludivine Labagnere; Harald Heider
Journal:  Microb Cell Fact       Date:  2017-03-23       Impact factor: 5.328

  4 in total

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