Literature DB >> 11425535

Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives.

A Scozzafava1, A Mastrolorenzo, C T Supuran.   

Abstract

A series of 9-sulfonylated/sulfenylated-6-mercaptopurines has been prepared by reaction of 6-mercaptopurine with sulfonyl/sulfenyl halides. These compounds constitute a new class of potent antimycobacterial agents, possessing MIC values against Mycobacterium tuberculosis H37Rv in the range of 0.39-3.39 microg/mL, as well as appreciable activity against Mycobacterium avium. Furthermore, a compound of this small series exhibited good activity (MIC under 1 microg/mL) against several drug resistant strains of M. tuberculosis.

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Year:  2001        PMID： 11425535     DOI： 10.1016/s0960-894x(01)00266-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  6-Oxo and 6-thio purine analogs as antimycobacterial agents.

Authors:  Ashish K Pathak; Vibha Pathak; Lainne E Seitz; William J Suling; Robert C Reynolds
Journal:  Bioorg Med Chem       Date:  2013-02-04       Impact factor: 3.641

2.  Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model.

Authors:  Rosemarie B Alcantara; Richard D A Read; Michelle Wright Valderas; Timothy D Brown; R Martin Roop
Journal:  Infect Immun       Date:  2004-08       Impact factor: 3.441

Review 3.  New small-molecule synthetic antimycobacterials.

Authors:  Lluis Ballell; Robert A Field; Ken Duncan; Robert J Young
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

4.  6-Chloro-9-(2-nitro-phenyl-sulfon-yl)-9H-purine.

Authors:  Ning-Yu Wang; Mei Deng; Yong Xia; Luo-Ting Yu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-02-23

Review 5.  Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies.

Authors:  Ashok Aspatwar; Jean-Yves Winum; Fabrizio Carta; Claudiu T Supuran; Milka Hammaren; Mataleena Parikka; Seppo Parkkila
Journal:  Molecules       Date:  2018-11-08       Impact factor: 4.411

6.  Cu(II) Complexes of 4-[(1E)-N-{2-[(Z)-Benzylidene-amino]ethyl}ethanimidoyl]benzene-1,3-diol Schiff Base: Synthesis, Spectroscopic, In-Vitro Antioxidant, Antifungal and Antibacterial Studies.

Authors:  Ikechukwu P Ejidike
Journal:  Molecules       Date:  2018-06-29       Impact factor: 4.411

Review 7.  Mycobacterium tuberculosis β-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs.

Authors:  Ashok Aspatwar; Visvaldas Kairys; Sangeetha Rala; Mataleena Parikka; Murat Bozdag; Fabrizio Carta; Claudiu T Supuran; Seppo Parkkila
Journal:  Int J Mol Sci       Date:  2019-10-17       Impact factor: 5.923
  7 in total

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