| Literature DB >> 11425534 |
S L Gwaltney1, H M Imade, Q Li, L Gehrke, R B Credo, R B Warner, J Y Lee, P Kovar, D Frost, S C Ng, H L Sham.
Abstract
The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.Entities:
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Year: 2001 PMID： 11425534 DOI： 10.1016/s0960-894x(01)00279-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823