| Literature DB >> 11425529 |
H C Kim1, T Nabeshima, W K Jhoo, K H Ko, W K Kim, E J Shin, M Cho, P H Lee.
Abstract
We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.Entities:
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Year: 2001 PMID： 11425529 DOI： 10.1016/s0960-894x(01)00262-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823