Literature DB >> 11425528

Biological evaluation of hepatitis C virus helicase inhibitors.

C W Phoon1, P Y Ng, A E Ting, S L Yeo, M M Sim.   

Abstract

A small chemical library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure-activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the linkers. Our data highlight the importance of preserving the aminophenylbenzimidazole core and the hydrophobic linkers for biological activity. The development of a robust HCV helicase assay is also described.

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Year:  2001        PMID： 11425528     DOI： 10.1016/s0960-894x(01)00263-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

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Journal:  RNA Biol       Date:  2010-11-01       Impact factor: 4.652

2.  Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents.

Authors:  Marcella Bassetto; Salvatore Ferla; Pieter Leyssen; Johan Neyts; Mark M Yerukhimovich; David N Frick; Rachel O'Donnell; Andrea Brancale
Journal:  Antivir Chem Chemother       Date:  2016-11-04

3.  Unique helicase determinants in the essential conjugative TraI factor from Salmonella enterica serovar Typhimurium plasmid pCU1.

Authors:  Krystle J McLaughlin; Rebekah P Nash; Mathew R Redinbo
Journal:  J Bacteriol       Date:  2014-06-16       Impact factor: 3.490

4.  HCV genetics and genotypes dictate future antiviral strategies.

Authors:  Louis Papageorgiou; Chrisanthy Vlachakis; Konstantina Dragoumani; Sofia Raftopoulou; Dimitrios Brouzas; Nicolas C Nicolaides; George P Chrousos; Evangelia Charmandari; Vasileios Megalooikonomou; Dimitrios Vlachakis
Journal:  J Mol Biochem       Date:  2017-12-10

5.  Detection of inhibition of bovine viral diarrhea virus by aromatic cationic molecules.

Authors:  M Daniel Givens; Christine C Dykstra; Kenny V Brock; David A Stringfellow; Arvind Kumar; Chad E Stephens; Hakan Goker; David W Boykin
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191

6.  Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor.

Authors:  Craig A Belon; Yoji D High; Tse-I Lin; Frederik Pauwels; David N Frick
Journal:  Biochemistry       Date:  2010-03-09       Impact factor: 3.162

Review 7.  The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target.

Authors:  David N Frick
Journal:  Curr Issues Mol Biol       Date:  2007-01       Impact factor: 2.081

8.  Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays.

Authors:  Sourav Mukherjee; Alicia M Hanson; William R Shadrick; Jean Ndjomou; Noreena L Sweeney; John J Hernandez; Diana Bartczak; Kelin Li; Kevin J Frankowski; Julie A Heck; Leggy A Arnold; Frank J Schoenen; David N Frick
Journal:  Nucleic Acids Res       Date:  2012-06-27       Impact factor: 16.971

9.  Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target.

Authors:  Dimitrios Vlachakis; Sophia Kossida
Journal:  PeerJ       Date:  2013-06-11       Impact factor: 2.984

10.  A holistic evolutionary and structural study of flaviviridae provides insights into the function and inhibition of HCV helicase.

Authors:  Dimitrios Vlachakis; Vassiliki Lila Koumandou; Sophia Kossida
Journal:  PeerJ       Date:  2013-05-07       Impact factor: 2.984
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