Literature DB >> 11425519

Cellular effects of 5-formyluracil in DNA.

S Bjelland1, H Anensen, I Knaevelsrud, E Seeberg.   

Abstract

5-Formyluracil is a major oxidation product of thymine, formed in DNA in yields comparable to that of 8-oxo-7,8-dihydroguanine by exposure to gamma-irradiation. Whereas the repair pathways for removal and the biological effects of persisting 8-oxo-7,8-dihydroguanine are much elucidated, much less attention has been paid to the cellular implications of 5-formyluracil in DNA. Here we review the present state of knowledge in this important area within research on oxidative DNA damage.

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Year:  2001        PMID： 11425519     DOI： 10.1016/s0921-8777(01)00085-4

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  5 in total

1.  Fragmentation of deprotonated ions of oligodeoxynucleotides carrying a 5-formyluracil or 2-aminoimidazolone.

Authors:  Yinsheng Wang; Lijie Men; Shetty Vivekananda
Journal:  J Am Soc Mass Spectrom       Date:  2002-10       Impact factor: 3.109

2.  Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein.

Authors:  Izumi Miyabe; Qiu-Mei Zhang; Katsuhito Kino; Hiroshi Sugiyama; Masashi Takao; Akira Yasui; Shuji Yonei
Journal:  Nucleic Acids Res       Date:  2002-08-01       Impact factor: 16.971

3.  Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine.

Authors:  Masaki Hori; Shin-Ichiro Yonekura; Takehiko Nohmi; Petr Gruz; Hiroshi Sugiyama; Shuji Yonei; Qiu-Mei Zhang-Akiyama
Journal:  J Nucleic Acids       Date:  2010-09-26

4.  KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli.

Authors:  Qiu-Mei Zhang-Akiyama; Hironobu Morinaga; Masahiro Kikuchi; Shin-Ichiro Yonekura; Hiroshi Sugiyama; Kazuo Yamamoto; Shuji Yonei
Journal:  Nucleic Acids Res       Date:  2009-02-17       Impact factor: 16.971

5.  Clustered DNA lesions containing 5-formyluracil and AP site: repair via the BER system.

Authors:  Ekaterina A Belousova; Inna A Vasil'eva; Nina A Moor; Timofey S Zatsepin; Tatiana S Oretskaya; Olga I Lavrik
Journal:  PLoS One       Date:  2013-08-06       Impact factor: 3.240
  5 in total

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