Literature DB >> 11423372

Phospholipid remodeling/generation in Giardia: the role of the Lands cycle.

S Das1, C Castillo, T Stevens.   

Abstract

Recent results suggest that Giardia is able to carry out deacylation/reacylation reactions (the Lands cycle) to generate new phospholipids, effectively bypassing the de novo synthesis of the entire phospholipid molecule. The successful operation of this deacylation/reacylation cycle is important for Giardia because this protozoan parasite possesses limited lipid synthesis ability. This article discusses how Giardia might use the Lands cycle to alter phospholipids acquired from the host during its colonization in the human small intestine.

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Year:  2001        PMID: 11423372     DOI: 10.1016/s1471-4922(01)01901-8

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN: 1471-4922


  17 in total

1.  Terminalia ferdinandiana extracts as inhibitors of Giardia duodenalis proliferation: a new treatment for giardiasis.

Authors:  P Rayan; B Matthews; P A McDonnell; I E Cock
Journal:  Parasitol Res       Date:  2015-04-16       Impact factor: 2.289

2.  Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia.

Authors:  Sasa Stefanić; Cornelia Spycher; Laura Morf; Gemma Fabriàs; Josefina Casas; Elisabeth Schraner; Peter Wild; Adrian B Hehl; Sabrina Sonda
Journal:  J Lipid Res       Date:  2010-03-24       Impact factor: 5.922

Review 3.  Sphingolipids in parasitic protozoa.

Authors:  Kai Zhang; James D Bangs; Stephen M Beverley
Journal:  Adv Exp Med Biol       Date:  2010       Impact factor: 2.622

4.  The assembly of GM1 glycolipid- and cholesterol-enriched raft-like membrane microdomains is important for giardial encystation.

Authors:  Atasi De Chatterjee; Tavis L Mendez; Sukla Roychowdhury; Siddhartha Das
Journal:  Infect Immun       Date:  2015-03-02       Impact factor: 3.441

Review 5.  Lipid metabolism in Giardia: a post-genomic perspective.

Authors:  M Yichoy; T T Duarte; A De Chatterjee; T L Mendez; K Y Aguilera; D Roy; S Roychowdhury; S B Aley; S Das
Journal:  Parasitology       Date:  2010-09-30       Impact factor: 3.234

6.  Glucosylceramide transferase activity is critical for encystation and viable cyst production by an intestinal protozoan, Giardia lamblia.

Authors:  Tavis L Mendez; Atasi De Chatterjee; Trevor T Duarte; Felipe Gazos-Lopes; Leobarda Robles-Martinez; Debarshi Roy; Jianjun Sun; Rosa A Maldonado; Sukla Roychowdhury; Igor C Almeida; Siddhartha Das
Journal:  J Biol Chem       Date:  2013-04-14       Impact factor: 5.157

7.  Lipidomic analysis reveals that phosphatidylglycerol and phosphatidylethanolamine are newly generated phospholipids in an early-divergent protozoan, Giardia lamblia.

Authors:  Mayte Yichoy; Ernesto S Nakayasu; Max Shpak; Clemente Aguilar; Stephen B Aley; Igor C Almeida; Siddhartha Das
Journal:  Mol Biochem Parasitol       Date:  2009-01-22       Impact factor: 1.759

8.  Novel role of sphingolipid synthesis genes in regulating giardial encystation.

Authors:  Yunuen Hernandez; Max Shpak; Trevor T Duarte; Tavis L Mendez; Rosa A Maldonado; Sukla Roychowdhury; Marcio L Rodrigues; Siddhartha Das
Journal:  Infect Immun       Date:  2008-04-21       Impact factor: 3.441

Review 9.  Regulation of the Golgi complex by phospholipid remodeling enzymes.

Authors:  Kevin D Ha; Benjamin A Clarke; William J Brown
Journal:  Biochim Biophys Acta       Date:  2012-04-22

10.  Ascorbic acid potentiates the Giardia duodenalis growth inhibitory activity of pure Terminalia ferdinandiana Exell compounds.

Authors:  I E Cock; P Rayan
Journal:  Parasitol Res       Date:  2020-01-06       Impact factor: 2.289

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