| Literature DB >> 11421799 |
F Fringuelli1, F Pizzo, L Vaccaro.
Abstract
Classical Lewis acids such as AlCl(3), TiCl(4), and SnCl(4), believed to be unusable as catalysts in aqueous medium, efficiently catalyzed regio- and stereoselective azidolysis and iodolysis of alpha,beta-epoxycarboxylic acids in water at pH 4.0 and 1.5, respectively. The concept of water-tolerant metal-salt is reexamined in direct relationship to the aqua ion hydrolysis constant.Entities:
Year: 2001 PMID： 11421799 DOI： 10.1021/jo010373y
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354