Literature DB >> 1142068

Selection of a reference partitioning system for drug design work.

R N Smith, C Hansch, M M Ames.   

Abstract

Consideration of the structural, polar, and transport properties of water-saturated solvent and solvent-saturated water phases of three general and eight specific binary systems leads to the conclusion that the n-octanol-water system is a very good all-round compromise for use as a reference system for biological partitioning in drug design work.

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Year:  1975        PMID： 1142068     DOI： 10.1002/jps.2600640405

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  8 in total

1.  Confocal microscopic analysis of transport mechanisms of insulin across the cell monolayer.

Authors:  Nikhil J Kavimandan; Nicholas A Peppas
Journal:  Int J Pharm       Date:  2007-12-23       Impact factor: 5.875

2.  Influence of derivation on the lipophilicity and inhibitory actions of cardiac glycosides on myocardial Na+-K+-ATPase.

Authors:  N Dzimiri; U Fricke; W Klaus
Journal:  Br J Pharmacol       Date:  1987-05       Impact factor: 8.739

3.  ICI 204448: a kappa-opioid agonist with limited access to the CNS.

Authors:  J S Shaw; J A Carroll; P Alcock; B G Main
Journal:  Br J Pharmacol       Date:  1989-04       Impact factor: 8.739

4.  On quantitative relationships between drug-like compound lipophilicity and plasma free fraction in monkey and human.

Authors:  Sami S Zoghbi; Kacey B Anderson; Kimberly J Jenko; David A Luckenbaugh; Robert B Innis; Victor W Pike
Journal:  J Pharm Sci       Date:  2011-12-13       Impact factor: 3.534

5.  Quantitative structure-activity relationship studies on nitrofuranyl anti-tubercular agents.

Authors:  Kirk E Hevener; David M Ball; John K Buolamwini; Richard E Lee
Journal:  Bioorg Med Chem       Date:  2008-07-29       Impact factor: 3.641

6.  The Thermodynamics of Partitioning of Phenothiazines between Phosphate Buffer and the Lipid Phases of Cyclohexane, n-Octanol and DMPC Liposomes.

Authors:  A M Ahmed; F H Farah; I W Kellaway
Journal:  Pharm Res       Date:  1985-05       Impact factor: 4.200

Review 7.  Development of quantitative structure-pharmacokinetic relationships.

Authors:  J M Mayer; H van de Waterbeemd
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031

8.  Chelation of Zinc with Biogenic Amino Acids: Description of Properties Using Balaban Index, Assessment of Biological Activity on Spirostomum Ambiguum Cellular Biosensor, Influence on Biofilms and Direct Antibacterial Action.

Authors:  Alla V Marukhlenko; Mariya A Morozova; Arsène M J Mbarga; Nadezhda V Antipova; Anton V Syroeshkin; Irina V Podoprigora; Tatiana V Maksimova
Journal:  Pharmaceuticals (Basel)       Date:  2022-08-09
  8 in total

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