Literature DB >> 11420610

Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice.

M K Purcell1, J L Mu, D C Higgins, R Elango, H Whitmore, S Harris, B Paigen.   

Abstract

Ath6 is a novel quantitative trait locus associated with differences in susceptibility to atherosclerosis between C57BL/6J (B6) and C57BLKS/J (BKS) inbred mouse strains. Combining data from an intercross and a backcross (1593 meioses) between mice from B6 and BKS strains and from The Jackson Laboratory interspecific backcross panels, (C57BL/6J x Mus spretus) F1 x C57BL/6J and (C57BL/6J x SPRET/Ei) F1 x SPRET/Ei, we constructed a consensus genetic map and narrowed Ath6 to a 1.07 +/- 0.26 cM interval between the anonymous DNA marker D12Pgn4 and the gene Nmyc1. This region is near the proximal end of murine Chromosome (Chr) 12, which is homologous to the human chromosomal region 2p24-p25. Marker order in the Ath6 region was concordant among the two crosses and The Jackson Laboratory interspecific backcross panels. This high resolution map rules out candidate genes encoding apolipoprotein B, syndecan 1, and Adam17. The two Ath6 crosses have a combined potential resolution of 0.06 cM.

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Year:  2001        PMID： 11420610     DOI： 10.1007/s00335001-0006-9

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  9 in total

1.  Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume.

Authors:  Luanne L Peters; Weidong Zhang; Amy J Lambert; Carlo Brugnara; Gary A Churchill; Orah S Platt
Journal:  Mamm Genome       Date:  2005-10-29       Impact factor: 2.957

Review 2.  Genetic basis of atherosclerosis: insights from mice and humans.

Authors:  Ioannis M Stylianou; Robert C Bauer; Muredach P Reilly; Daniel J Rader
Journal:  Circ Res       Date:  2012-01-20       Impact factor: 17.367

Review 3.  Identifying novel genes for atherosclerosis through mouse-human comparative genetics.

Authors:  Xiaosong Wang; Naoki Ishimori; Ron Korstanje; Jarod Rollins; Beverly Paigen
Journal:  Am J Hum Genet       Date:  2005-05-19       Impact factor: 11.025

4.  Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice.

Authors:  Daniel Teupser; Marietta Tan; Adam D Persky; Jan L Breslow
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-27       Impact factor: 11.205

Review 5.  The Role of ADAM17 in Inflammation-Related Atherosclerosis.

Authors:  Bai-Yi Tang; Jin Ge; Yang Wu; Juan Wen; Xiao-Hong Tang
Journal:  J Cardiovasc Transl Res       Date:  2022-06-01       Impact factor: 4.132

6.  Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient mice.

Authors:  Lesca M Holdt; Joachim Thiery; Jan L Breslow; Daniel Teupser
Journal:  Arterioscler Thromb Vasc Biol       Date:  2008-03-20       Impact factor: 8.311

7.  High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number between two Drosophila species.

Authors:  Virginie Orgogozo; Karl W Broman; David L Stern
Journal:  Genetics       Date:  2006-02-19       Impact factor: 4.562

8.  Identification of two cerebral malaria resistance loci using an inbred wild-derived mouse strain.

Authors:  Sébastien Bagot; Susana Campino; Carlos Penha-Gonçalves; Sylviane Pied; Pierre-André Cazenave; Dan Holmberg
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-11       Impact factor: 11.205

9.  Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice.

Authors:  Veronica V Colinayo; Jian-Hua Qiao; Xuping Wang; Kelly L Krass; Eric Schadt; Aldons J Lusis; Thomas A Drake
Journal:  Mamm Genome       Date:  2003-07       Impact factor: 2.957
  9 in total

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