B K Dolberg1, M J Lenhard. 1. Department of Medicine, Riddle Memorial Hospital, Media, Pennsylvania, USA.
Abstract
OBJECTIVE: To report the first known case of a successful outcome of pregnancy in a patient with generalized lipoatrophic diabetes. METHODS: We present a detailed case report of a patient who achieved and successfully completed a pregnancy despite having lipoatrophic diabetes. RESULTS: With careful attention to glycemic control with use of U-500 insulin and strict avoidance of dietary fat, a 23-year-old woman with lipoatrophic diabetes maintained a pregnancy to 28 weeks. The infant weighed 1,235 g and was devoid of serious metabolic complications. Three months after childbirth, the patient died of gastrointestinal bleeding. CONCLUSION: We are not aware of any previously published report of a successful pregnancy in a patient with generalized, acquired lipoatrophic diabetes. Because of the involvement of multiple organ systems in generalized lipoatrophic diabetes, female patients should be thoroughly advised of the serious pregnancy-associated risks to both the mother and the fetus and the need for extremely close monitoring.
OBJECTIVE: To report the first known case of a successful outcome of pregnancy in a patient with generalized lipoatrophic diabetes. METHODS: We present a detailed case report of a patient who achieved and successfully completed a pregnancy despite having lipoatrophic diabetes. RESULTS: With careful attention to glycemic control with use of U-500 insulin and strict avoidance of dietary fat, a 23-year-old woman with lipoatrophic diabetes maintained a pregnancy to 28 weeks. The infant weighed 1,235 g and was devoid of serious metabolic complications. Three months after childbirth, the patient died of gastrointestinal bleeding. CONCLUSION: We are not aware of any previously published report of a successful pregnancy in a patient with generalized, acquired lipoatrophic diabetes. Because of the involvement of multiple organ systems in generalized lipoatrophic diabetes, female patients should be thoroughly advised of the serious pregnancy-associated risks to both the mother and the fetus and the need for extremely close monitoring.