Literature DB >> 11418223

Evolution, language and analogy in functional genomics.

S A Benner1, E A Gaucher.   

Abstract

Almost a century ago, Wittgenstein pointed out that theory in science is intricately connected to language. This connection is not a frequent topic in the genomics literature. But a case can be made that functional genomics is today hindered by the paradoxes that Wittgenstein identified. If this is true, until these paradoxes are recognized and addressed, functional genomics will continue to be limited in its ability to extrapolate information from genomic sequences.

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Year:  2001        PMID: 11418223     DOI: 10.1016/s0168-9525(01)02320-4

Source DB:  PubMed          Journal:  Trends Genet        ISSN: 0168-9525            Impact factor:   11.639


  7 in total

1.  The identification of functional modules from the genomic association of genes.

Authors:  Berend Snel; Peer Bork; Martijn A Huynen
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-30       Impact factor: 11.205

2.  Purifying selection on leptin genes in teleosts may be due to poikilothermy.

Authors:  Shanchen Wang; Rixin Wang; Tianjun Xu
Journal:  J Genet       Date:  2014-08       Impact factor: 1.166

3.  Exploiting models of molecular evolution to efficiently direct protein engineering.

Authors:  Megan F Cole; Eric A Gaucher
Journal:  J Mol Evol       Date:  2010-12-04       Impact factor: 2.395

Review 4.  Utilizing natural diversity to evolve protein function: applications towards thermostability.

Authors:  Megan F Cole; Eric A Gaucher
Journal:  Curr Opin Chem Biol       Date:  2011-04-04       Impact factor: 8.822

5.  The evolutionary history of the catenin gene family during metazoan evolution.

Authors:  Zi-Ming Zhao; Albert B Reynolds; Eric A Gaucher
Journal:  BMC Evol Biol       Date:  2011-07-08       Impact factor: 3.260

6.  Evidence for positive selection on the leptin gene in Cetacea and Pinnipedia.

Authors:  Li Yu; Wei Jin; Xin Zhang; Ding Wang; Jin-song Zheng; Guang Yang; Shi-xia Xu; Soochin Cho; Ya-ping Zhang
Journal:  PLoS One       Date:  2011-10-27       Impact factor: 3.240

7.  Interchanging functionality among homologous elongation factors using signatures of heterotachy.

Authors:  Ercan Cacan; James T Kratzer; Megan F Cole; Eric A Gaucher
Journal:  J Mol Evol       Date:  2013-01-31       Impact factor: 2.395

  7 in total

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