BACKGROUND: We previously reported that cocaine-dependent patients with a reduced blue cone b wave electroretinogram (ERG) responses had significantly more cue-elicited craving. METHODS: A new series of 21 recently withdrawn cocaine-dependent patients completed a craving questionnaire at baseline and following cue exposure; an ERG was also performed. RESULTS: Cocaine-dependent patients with a blunted ERG blue cone response (<0.5 microV) showed greater increases in craving following cue exposure. When subjects were included from our preliminary study (N = 14), these differences became highly significant. CONCLUSIONS: Patients with a reduced ERG response may represent a subgroup more vulnerable to cocaine craving and future relapse.
BACKGROUND: We previously reported that cocaine-dependent patients with a reduced blue cone b wave electroretinogram (ERG) responses had significantly more cue-elicited craving. METHODS: A new series of 21 recently withdrawn cocaine-dependent patients completed a craving questionnaire at baseline and following cue exposure; an ERG was also performed. RESULTS:Cocaine-dependent patients with a blunted ERG blue cone response (<0.5 microV) showed greater increases in craving following cue exposure. When subjects were included from our preliminary study (N = 14), these differences became highly significant. CONCLUSIONS:Patients with a reduced ERG response may represent a subgroup more vulnerable to cocaine craving and future relapse.
Authors: David Smelson; Lei Yu; Steven Buyske; Gerardo Gonzalez; Jay Tischfield; Curtis K Deutsch; Douglas Ziedonis Journal: Am J Addict Date: 2012 Sep-Oct
Authors: David H Root; Anthony T Fabbricatore; David J Barker; Sisi Ma; Anthony P Pawlak; Mark O West Journal: PLoS One Date: 2009-09-25 Impact factor: 3.240