Literature DB >> 11417871

Heparin column analysis of serum type 5 tartrate-resistant acid phosphatase isoforms.

Y Igarashi1, M Y Lee, S Matsuzaki.   

Abstract

The objective of the present study was to develop a specific method for the separation of tartrate-resistant acid phosphatase (TRAP) derived exclusively from osteoclasts. Heparin column-bound TRAP in human serum was separated into three peaks of TRAP activity when eluted with a linear gradient of sodium chloride. The last peak corresponded to TRAP 5b which was first named according to its electrophoretic mobility [Clin. Chem. 24 (1978) 309] and was considered to be derived from osteoclasts [J. Bone Miner. Res. 13 (1998) 683]. The second peak was found to be TRAP 5a. The height of the last peak varied from age to age.

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Year:  2001        PMID： 11417871     DOI： 10.1016/s0378-4347(01)00157-8

Source DB:  PubMed          Journal:  J Chromatogr B Biomed Sci Appl        ISSN： 1387-2273


  4 in total

1.  Differential expression of tartrate-resistant acid phosphatase isoforms 5a and 5b by tumor and stromal cells in human metastatic bone disease.

Authors:  Serhan Zenger; Wentao He; Barbro Ek-Rylander; Daphne Vassiliou; Rickard Wedin; Henrik Bauer; Göran Andersson
Journal:  Clin Exp Metastasis       Date:  2010-10-22       Impact factor: 5.150

2.  Reference intervals of serum tartrate-resistant acid phosphatase type 5b activity measured with a novel assay in Japanese subjects.

Authors:  Yoshiki Nishizawa; Masaaki Inaba; Mitsukazu Ishii; Hiroyuki Yamashita; Takami Miki; Hitoshi Goto; Sinsuke Yamada; Osamu Chaki; Kentaro Kurasawa; Yoshiko Mochizuki
Journal:  J Bone Miner Metab       Date:  2008-05-11       Impact factor: 2.626

3.  A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages.

Authors:  Carian E Boorsma; T Anienke van der Veen; Kurnia S S Putri; Andreia de Almeida; Christina Draijer; Thais Mauad; Gyorgy Fejer; Corry-Anke Brandsma; Maarten van den Berge; Yohan Bossé; Don Sin; Ke Hao; Anja Reithmeier; Göran Andersson; Peter Olinga; Wim Timens; Angela Casini; Barbro N Melgert
Journal:  Sci Rep       Date:  2017-10-03       Impact factor: 4.379

4.  Cathepsin K regulates localization and secretion of Tartrate-Resistant Acid Phosphatase (TRAP) in TRAP-overexpressing MDA-MB-231 breast cancer cells.

Authors:  Anja Reithmeier; Maria Norgård; Barbro Ek-Rylander; Tuomas Näreoja; Göran Andersson
Journal:  BMC Mol Cell Biol       Date:  2020-03-18
  4 in total

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