Effect of carbon dioxide tension in the first three days of life on the development of retinopathy of prematurity.

BACKGROUND: This study focuses on the effect of carbon dioxide tension in the first 3 days of life on the development of retinopathy of prematurity (ROP) in mechanically ventilated premature infants.
METHODS: From January 1997 to June 1998, 91 premature infants (gestational age 28.8 +/- 2.5 weeks, birth weight 1169 +/- 385 g) born in Chung Gung Children's Hospital requiring mechanical ventilation in the first 72 hours were enrolled in our study. Ophthalmic examination was performed initially at 4-6 weeks of age and then every week if ROP was found and every other week if the result was normal until discharge. These infants were divided into 2 groups: those with and without ROP. Medical records of the highest and lowest blood gas measurements were recorded during the first 3 days of life. To screen for possible risk factors related to the development of ROP within these 2 groups, variables comprising perinatal data were compared.
RESULTS: The perinatal factors were compared, whish showed that infants with ROP had a lower mean gestational age (p < 0.001), mean birth body weight (p < 0.001), and a longer duration under mechanical ventilation (p < 0.001). The severity and incidence of ROP were not affected by either hypercapnia or hypocapnia; even with the superimposed effect of hyperoxia, the effect was minimal.
CONCLUSION: Hypercarbia or hypocarbia in the first 3 days of mechanically ventilated preterm neonates does not affect the subsequent development of retinopathy of prematurity. However, a lower gestational age and birth weight as well as longer-duration mechanical ventilation might be independent predictors for the occurrence of ROP. The role of PaCO2 in the pathophysiology of retinopathy of prematurity remains undetermined, and further investigation in the future is warranted.