Literature DB >> 11416882

Human surfactant protein A (SP-A) variants: why so many, why such a complexity?

J Floros1.   

Abstract

Human surfactant protein A (SP-A) exhibits extensive complexity at several levels: genetic, transcript (splicing), protein, and composition and size of protein oligomers. Its multiple and important roles in innate host defense, regulation of inflammation, and in aspects of pulmonary surfactant may have necessitated such a complexity from an evolutionary point of view. Moreover, understanding of such a complexity may be useful in the study of disease pathogenesis and the development of disease diagnostics and/or therapeutics.

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Year:  2001        PMID： 11416882     DOI： 2001/07/smw-06136

Source DB:  PubMed          Journal:  Swiss Med Wkly        ISSN： 0036-7672            Impact factor:   2.193


  8 in total

1.  Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A.

Authors:  Matthew W Foster; J Will Thompson; Julie G Ledford; Laura G Dubois; John W Hollingsworth; Dave Francisco; Sasipa Tanyaratsrisakul; Dennis R Voelker; Monica Kraft; M Arthur Moseley; W Michael Foster
Journal:  J Proteome Res       Date:  2014-07-15       Impact factor: 4.466

2.  An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture.

Authors:  Patricia Silveyra; Susan L DiAngelo; Joanna Floros
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2014-05-02       Impact factor: 5.464

3.  The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation.

Authors:  Patricia Silveyra; Manmeet Raval; Brett Simmons; Susan Diangelo; Guirong Wang; Joanna Floros
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2011-08-12       Impact factor: 5.464

4.  Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants.

Authors:  Nikolaos Tsotakos; Patricia Silveyra; Zhenwu Lin; Neal Thomas; Mudit Vaid; Joanna Floros
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2014-10-17       Impact factor: 5.464

Review 5.  Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2.

Authors:  Patricia Silveyra; Joanna Floros
Journal:  Gene       Date:  2012-10-12       Impact factor: 3.688

Review 6.  Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury.

Authors:  Patricia Silveyra; Joanna Floros
Journal:  Front Biosci (Landmark Ed)       Date:  2012-01-01

7.  Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A.

Authors:  Ata Abbasi; David S Phelps; Radhika Ravi; Joanna Floros
Journal:  Antioxidants (Basel)       Date:  2021-04-22

8.  Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction.

Authors:  Helen Ilumets; Witold Mazur; Tuula Toljamo; Noora Louhelainen; Pentti Nieminen; Hideo Kobayashi; Nobuhisa Ishikawa; Vuokko L Kinnula
Journal:  BMC Pulm Med       Date:  2011-04-19       Impact factor: 3.317
  8 in total

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