Literature DB >> 11416172

Protection from superoxide damage associated with an increased level of the YggX protein in Salmonella enterica.

J Gralnick1, D Downs.   

Abstract

The deleterious effect of superoxide radicals on cell growth and survival is predominantly caused by rapid oxidation of labile [Fe-S] clusters in proteins. Oxidation of these clusters releases Fe(II) ions, which participate in Fenton chemistry that damages DNA. Here it is shown that elevated levels of the YggX protein increase the resistance of Salmonella enterica to superoxide stress, reverse enzymatic defects attributed to oxidized [Fe-S] clusters, and decrease the spontaneous mutation frequency. The data are consistent with a model in which YggX protects protein [Fe-S] clusters from oxidation.

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Year:  2001        PMID： 11416172      PMCID： PMC35462          DOI： 10.1073/pnas.151243198

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  56 in total

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3.  Induction of the soxRS regulon of Escherichia coli by superoxide.

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Journal:  J Biol Chem       Date:  1999-04-02       Impact factor: 5.157

4.  Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli.

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Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

5.  Non heme (iron-sulfur) proteins of Azotobacter vinelandii.

Authors:  Y I Shethna; D V DerVartanian; H Beinert
Journal:  Biochem Biophys Res Commun       Date:  1968-06-28       Impact factor: 3.575

6.  A periplasmic location is essential for the role of the ApbE lipoprotein in thiamine synthesis in Salmonella typhimurium.

Authors:  B J Beck; D M Downs
Journal:  J Bacteriol       Date:  1999-12       Impact factor: 3.490

7.  Small broad-host-range gentamycin resistance gene cassettes for site-specific insertion and deletion mutagenesis.

Authors:  H D Schweizer
Journal:  Biotechniques       Date:  1993-11       Impact factor: 1.993

8.  The apbE gene encodes a lipoprotein involved in thiamine synthesis in Salmonella typhimurium.

Authors:  B J Beck; D M Downs
Journal:  J Bacteriol       Date:  1998-02       Impact factor: 3.490

9.  Evidence that rseC, a gene in the rpoE cluster, has a role in thiamine synthesis in Salmonella typhimurium.

Authors:  B J Beck; L E Connolly; A De Las Peñas; D M Downs
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

10.  Two genetically-distinct and differentially-regulated aconitases (AcnA and AcnB) in Escherichia coli.

Authors:  M J Gruer; J R Guest
Journal:  Microbiology (Reading)       Date:  1994-10       Impact factor: 2.777
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  21 in total

1.  Lack of the ApbC or ApbE protein results in a defect in Fe-S cluster metabolism in Salmonella enterica serovar Typhimurium.

Authors:  Elizabeth Skovran; Diana M Downs
Journal:  J Bacteriol       Date:  2003-01       Impact factor: 3.490

2.  SoxRS-regulated expression and genetic analysis of the yggX gene of Escherichia coli.

Authors:  Pablo J Pomposiello; Anastasia Koutsolioutsou; Daniel Carrasco; Bruce Demple
Journal:  J Bacteriol       Date:  2003-11       Impact factor: 3.490

Review 3.  How Is Fe-S Cluster Formation Regulated?

Authors:  Erin L Mettert; Patricia J Kiley
Journal:  Annu Rev Microbiol       Date:  2015       Impact factor: 15.500

4.  The solution structure of the oxidative stress-related protein YggX from Escherichia coli.

Authors:  Michael J Osborne; Nadeem Siddiqui; Dirk Landgraf; Pablo J Pomposiello; Kalle Gehring
Journal:  Protein Sci       Date:  2005-05-09       Impact factor: 6.725

5.  Bacterial ApbC protein has two biochemical activities that are required for in vivo function.

Authors:  Jeffrey M Boyd; Jamie L Sondelski; Diana M Downs
Journal:  J Biol Chem       Date:  2008-11-10       Impact factor: 5.157

6.  Contrasting sensitivities of Escherichia coli aconitases A and B to oxidation and iron depletion.

Authors:  Shery Varghese; Yue Tang; James A Imlay
Journal:  J Bacteriol       Date:  2003-01       Impact factor: 3.490

7.  Thiamine biosynthesis can be used to dissect metabolic integration.

Authors:  Mark J Koenigsknecht; Diana M Downs
Journal:  Trends Microbiol       Date:  2010-04-08       Impact factor: 17.079

8.  Phosphoribosylpyrophosphate synthetase (PrsA) variants alter cellular pools of ribose 5-phosphate and influence thiamine synthesis in Salmonella enterica.

Authors:  Mark J Koenigsknecht; Luke A Fenlon; Diana M Downs
Journal:  Microbiology (Reading)       Date:  2009-12-03       Impact factor: 2.777

9.  Expression of a heterologous manganese superoxide dismutase gene in intestinal lactobacilli provides protection against hydrogen peroxide toxicity.

Authors:  Jose M Bruno-Bárcena; Jason M Andrus; Stephen L Libby; Todd R Klaenhammer; Hosni M Hassan
Journal:  Appl Environ Microbiol       Date:  2004-08       Impact factor: 4.792

10.  Quantifying changes in the thiol redox proteome upon oxidative stress in vivo.

Authors:  Lars I Leichert; Florian Gehrke; Harini V Gudiseva; Tom Blackwell; Marianne Ilbert; Angela K Walker; John R Strahler; Philip C Andrews; Ursula Jakob
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-14       Impact factor: 11.205
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