Literature DB >> 11416131

Novel CD28-responsive enhancer activated by CREB/ATF and AP-1 families in the human interleukin-2 receptor alpha-chain locus.

J H Yeh1, P Lecine, J A Nunes, S Spicuglia, P Ferrier, D Olive, J Imbert.   

Abstract

The interaction of interleukin-2 (IL-2) with its receptor (IL-2R) critically regulates the T-cell immune response, and the alpha chain CD25/IL-2Ralpha is required for the formation of the high-affinity receptor. Tissue-specific, inducible expression of the IL-2Ralpha gene is regulated by at least three positive regulatory regions (PRRI, PRRII, and PRRIII), but none responded to CD28 engagement in gene reporter assays although CD28 costimulation strongly amplifies IL-2Ralpha gene transcription. By DNase I hypersensitivity analysis, we have identified a novel TCR-CD3- and CD28-responsive enhancer (CD28rE) located 8.5 kb 5' of the IL-2Ralpha gene. PRRIV/CD28rE contains a functional CRE/TRE element required for CD28 signaling. The T-cell-specific, CD28-responsive expression of the IL-2Ralpha gene appears controlled through PRRIV/CD28rE by cooperation of CREB/ATF and AP-1 family transcription factors.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11416131      PMCID： PMC87111          DOI： 10.1128/MCB.21.14.4515-4527.2001

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  67 in total

1.  The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

Authors:  P Ghosh; T H Tan; N R Rice; A Sica; H A Young
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

2.  A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement.

Authors:  R Siefken; S Klein-Hessling; E Serfling; R Kurrle; R Schwinzer
Journal:  J Immunol       Date:  1998-08-15       Impact factor: 5.422

3.  Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28.

Authors:  M Li-Weber; M Giasi; P H Krammer
Journal:  J Biol Chem       Date:  1998-12-04       Impact factor: 5.157

4.  Prolonged IL-2 receptor alpha/CD25 expression after T cell activation via the adhesion molecules CD2 and CD28. Demonstration of combined transcriptional and post-transcriptional regulation.

Authors:  C Cerdan; Y Martin; M Courcoul; H Brailly; C Mawas; F Birg; D Olive
Journal:  J Immunol       Date:  1992-10-01       Impact factor: 5.422

5.  Evidence for a role of CD28RE as a response element for distinct mitogenic T cell activation signals.

Authors:  A Civil; M Geerts; L A Aarden; C L Verweij
Journal:  Eur J Immunol       Date:  1992-11       Impact factor: 5.532

6.  Aphidicolin-induced proliferative arrest of murine mast cells: morphological and biochemical changes are not accompanied by alterations in cytokine gene induction.

Authors:  J J Costa; J M Keffer; J P Goff; D D Metcalfe
Journal:  Immunology       Date:  1992-07       Impact factor: 7.397

7.  Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.

Authors:  J D Fraser; A Weiss
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

Review 8.  Biology of the interleukin-2 receptor.

Authors:  B H Nelson; D M Willerford
Journal:  Adv Immunol       Date:  1998       Impact factor: 3.543

9.  Nuclear translocation and DNA recognition signals colocalized within the bZIP domain of cyclic adenosine 3',5'-monophosphate response element-binding protein CREB.

Authors:  G Waeber; J F Habener
Journal:  Mol Endocrinol       Date:  1991-10

10.  Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.

Authors:  M Nichols; F Weih; W Schmid; C DeVack; E Kowenz-Leutz; B Luckow; M Boshart; G Schütz
Journal:  EMBO J       Date:  1992-09       Impact factor: 11.598
View more
  13 in total

1.  Human mucosal CD4+ T cells but not blood CD4+ T cells respond vigorously towards CD28 engagement.

Authors:  J Schröder-Braunstein; V Pavlov; T Giese; A Heidtmann; S Wentrup; F Lasitschka; J Winter; A Ulrich; A Engelke; M Al Saeedi; S Meuer
Journal:  Clin Exp Immunol       Date:  2012-04       Impact factor: 4.330

2.  Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression.

Authors:  Marie-Pierre Belot; Anne-Laure Castell; Sophie Le Fur; Pierre Bougnères
Journal:  Epigenetics       Date:  2018-08-10       Impact factor: 4.528

3.  An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment.

Authors:  Liang Zhou; Aaron A Nazarian; Jian Xu; Dean Tantin; Lynn M Corcoran; Stephen T Smale
Journal:  Mol Cell Biol       Date:  2007-01-22       Impact factor: 4.272

4.  Predominant contribution of DGKζ over DGKα in the control of PKC/PDK-1-regulated functions in T cells.

Authors:  Antonia Ávila-Flores; Javier Arranz-Nicolás; Elena Andrada; Denise Soutar; Isabel Mérida
Journal:  Immunol Cell Biol       Date:  2017-02-06       Impact factor: 5.126

Review 5.  The role of the transcription factor CREB in immune function.

Authors:  Andy Y Wen; Kathleen M Sakamoto; Lloyd S Miller
Journal:  J Immunol       Date:  2010-12-01       Impact factor: 5.422

6.  Control of IL-2Ralpha gene expression: structural changes within the proximal enhancer/core promoter during T-cell development.

Authors:  Jung-Hua Yeh; Salvatore Spicuglia; Sanjeex Kumar; Albert Sanchez-Sevilla; Pierre Ferrier; Jean Imbert
Journal:  Nucleic Acids Res       Date:  2002-05-01       Impact factor: 16.971

7.  Pertussis toxin utilizes proximal components of the T-cell receptor complex to initiate signal transduction events in T cells.

Authors:  Olivia D Schneider; Alison A Weiss; William E Miller
Journal:  Infect Immun       Date:  2007-06-11       Impact factor: 3.441

8.  CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen.

Authors:  Buka Samten; James C Townsend; Steven E Weis; Anindita Bhoumik; Peter Klucar; Homayoun Shams; Peter F Barnes
Journal:  J Immunol       Date:  2008-08-01       Impact factor: 5.422

9.  IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility.

Authors:  Fuencisla Matesanz; Alfredo Caro-Maldonado; Maria Fedetz; Oscar Fernández; Roger L Milne; Miguel Guerrero; Concepción Delgado; Antonio Alcina
Journal:  J Neurol       Date:  2007-04-10       Impact factor: 4.849

10.  The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements.

Authors:  Hyoung-Pyo Kim; Warren J Leonard
Journal:  EMBO J       Date:  2002-06-17       Impact factor: 11.598
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.