Literature DB >> 1141399

Sensitive method for the routine determination tricyclic antidepressants in plasma using a specific nitrogen detector.

L A Gifford, P Turner, C M Pare.   

Abstract

The sensitivity of the alkali flame ionization detector to the tricyclic antidepressant drugs has been studied and limits of detection measured. A backflush system has been used to enable measurement in plasma extracts. A general method for the estimation of tricyclic plasma levels has been developed and exemplified by the measurement of imipramine at therapeutic levels.

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Year:  1975        PMID： 1141399     DOI： 10.1016/s0021-9673(01)81094-3

Source DB:  PubMed          Journal:  J Chromatogr


  10 in total

1.  Studies of the interaction of desmethylimipramine with tyramine in man after a single oral dose, and its correlation with plasma concentration.

Authors:  K Ghose; L A Gifford; P Turner; M Leighton
Journal:  Br J Clin Pharmacol       Date:  1976-04       Impact factor: 4.335

2.  Sensitive method for the determination of tandamine hydrochloride in plasma using a specific nitrogen detector.

Authors:  L A Gifford; D J Witts
Journal:  Br J Clin Pharmacol       Date:  1976-04       Impact factor: 4.335

3.  A single comprehensive gas chromatographic assay for tricyclic and tetracyclic antidepressant drugs and their major metabolites in plasma.

Authors:  D J Witts; P Turner
Journal:  Br J Clin Pharmacol       Date:  1977-04       Impact factor: 4.335

Review 4.  Plasma level monitoring of tricyclic antidepressant therapy.

Authors:  L F Gram
Journal:  Clin Pharmacokinet       Date:  1977 Jul-Aug       Impact factor: 6.447

5.  Some clinical pharmacological studies with butriptyline, an antidepressive drug.

Authors:  K Ghose; G J Huston; M J Kirby; D J Witts; P Turner
Journal:  Br J Clin Pharmacol       Date:  1977-02       Impact factor: 4.335

6.  Antidepressant blood levels in acute overdose.

Authors:  C Hallstrom; L Gifford
Journal:  Postgrad Med J       Date:  1976-11       Impact factor: 2.401

Review 7.  Clinical pharmacokinetics of clomipramine.

Authors:  A E Balant-Gorgia; M Gex-Fabry; L P Balant
Journal:  Clin Pharmacokinet       Date:  1991-06       Impact factor: 6.447

Review 8.  Antidepressant toxicity and the need for identification and concentration monitoring in overdose.

Authors:  B M Power; L P Hackett; L J Dusci; K F Ilett
Journal:  Clin Pharmacokinet       Date:  1995-09       Impact factor: 6.447

9.  Clinical pharmacological studies of tandamine, a potential antidepressive drug.

Authors:  R S Ehsanullah; K Ghose; M J Kirby; P Turner; D Witts
Journal:  Psychopharmacology (Berl)       Date:  1977-03-23       Impact factor: 4.530

Review 10.  Clinical pharmacokinetics of drugs used to treat urge incontinence.

Authors:  David R P Guay
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447
  10 in total

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