Literature DB >> 11413013

Ran GTPase cycle: oOne mechanism -- two functions.

F Melchior1.   

Abstract

The Ras-related GTPase Ran functions in nucleocytoplasmic transport by regulating interactions of transport receptors with transport cargo. Three recent studies suggest that Ran uses exactly the same mechanism to regulate spindle assembly during mitosis.

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Year:  2001        PMID： 11413013     DOI： 10.1016/s0960-9822(01)00132-4

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  4 in total

1.  Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.

Authors:  Guy Keryer; Barbara Di Fiore; Claude Celati; Karl Ferdinand Lechtreck; Mette Mogensen; Annie Delouvee; Patrizia Lavia; Michel Bornens; Anne-Marie Tassin
Journal:  Mol Biol Cell       Date:  2003-07-11       Impact factor: 4.138

2.  G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.

Authors:  Alyssa N Coyne; Benjamin L Zaepfel; Lindsey Hayes; Boris Fitchman; Yuval Salzberg; En-Ching Luo; Kelly Bowen; Hannah Trost; Stefan Aigner; Frank Rigo; Gene W Yeo; Amnon Harel; Clive N Svendsen; Dhruv Sareen; Jeffrey D Rothstein
Journal:  Neuron       Date:  2020-07-15       Impact factor: 17.173

3.  Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS.

Authors:  Alyssa N Coyne; Victoria Baskerville; Benjamin L Zaepfel; Dennis W Dickson; Frank Rigo; Frank Bennett; C Patrick Lusk; Jeffrey D Rothstein
Journal:  Sci Transl Med       Date:  2021-07-28       Impact factor: 19.319

4.  Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid.

Authors:  Kiyoshi Tahara; Masatoshi Takagi; Miho Ohsugi; Takefumi Sone; Fumiko Nishiumi; Kazuhiro Maeshima; Yasuomi Horiuchi; Noriko Tokai-Nishizumi; Fumio Imamoto; Tadashi Yamamoto; Shingo Kose; Naoko Imamoto
Journal:  J Cell Biol       Date:  2008-02-11       Impact factor: 10.539
  4 in total

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