| Literature DB >> 11412990 |
T J Zahn1, J Whitney, C Weinbaum, R A Gibbs.
Abstract
A stereocontrolled synthetic route has been used to prepare two of the geometric isomers of all-trans-GGPP. Neither of these isomers is effective substrates for mammalian GGTase I, but 3 is a potent inhibitor of this enzyme (IC(50)=100 nM). Surprisingly, both compounds are effective substrates for mammalian FTase.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11412990 DOI： 10.1016/s0960-894x(01)00292-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823