Literature DB >> 11412988

The cyclohexene ring as bioisostere of a furanose ring: synthesis and antiviral activity of cyclohexenyl nucleosides.

P Herdewijn1, E De Clercq.   

Abstract

The application of the bioisosteric concept between a furanose ring and a cyclohexene ring in the nucleoside field has led to the discovery of new potent antiviral agents.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11412988     DOI： 10.1016/s0960-894x(01)00270-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2'-fluoro RNA.

Authors:  Punit P Seth; Jinghua Yu; Ali Jazayeri; Pradeep S Pallan; Charles R Allerson; Michael E Østergaard; Fengwu Liu; Piet Herdewijn; Martin Egli; Eric E Swayze
Journal:  J Org Chem       Date:  2012-05-18       Impact factor: 4.354

2.  Cyclohexenyl nucleic acids: conformationally flexible oligonucleotides.

Authors:  Koen Nauwelaerts; Eveline Lescrinier; Gert Sclep; Piet Herdewijn
Journal:  Nucleic Acids Res       Date:  2005-04-29       Impact factor: 16.971

Review 3.  Smart functional nucleic acid chimeras: enabling tissue specific RNA targeting therapy.

Authors:  Lukas J Aaldering; Hossam Tayeb; Shilpa Krishnan; Susan Fletcher; Stephen D Wilton; Rakesh N Veedu
Journal:  RNA Biol       Date:  2015       Impact factor: 4.652

Review 4.  The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold.

Authors:  Katherine L Seley-Radtke; Mary K Yates
Journal:  Antiviral Res       Date:  2018-04-10       Impact factor: 10.103
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.