| Literature DB >> 11412983 |
A S Bessis1, J Bolte, J P Pin, F Acher.
Abstract
The (2S,4R)- and (2S,4S)-4-hydroxyglutamates activate cloned mGlu(1a), mGlu(2), and mGlu(8a) receptors with different potencies. Best results were obtained with the (2S,4S) isomer being almost as potent as glutamate on mGlu(1a)R and mGlu(8a)R. Data are interpreted on the basis of the binding site model and X-ray structure.Entities:
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Year: 2001 PMID： 11412983 DOI： 10.1016/s0960-894x(01)00158-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823