| Literature DB >> 11412980 |
M L Curtin1, A S Florjancic, H R Heyman, M R Michaelides, R B Garland, J H Holms, D H Steinman, J F Dellaria, J Gong, C K Wada, Y Guo, I B Elmore, P Tapang, D H Albert, T J Magoc, P A Marcotte, J J Bouska, C L Goodfellow, J L Bauch, K C Marsh, D W Morgan, S K Davidsen.
Abstract
Modification of the biphenyl portion of MMP inhibitor 2a gave analogue 2i which is greater than 1000-fold selective against MMP-2 versus MMP-1. The stereospecific synthesis of both enantiomers of 2i was achieved beginning with (S)- or (R)-benzyl glycidyl ether. The (S)-enantiomer, 11 (ABT-770), is orally bioavailable and efficacious in an in vivo model of tumor growth.Entities:
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Year: 2001 PMID： 11412980 DOI： 10.1016/s0960-894x(01)00032-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823