| Literature DB >> 11412977 |
M A Weidner-Wells1, K A Ohemeng, V N Nguyen, S Fraga-Spano, M J Macielag, H M Werblood, B D Foleno, G C Webb, J F Barrett, D J Hlasta.
Abstract
Amidino benzimidazoles have been identified as inhibitors of the bacterial KinA/Spo0F two-component system (TCS). Many of these inhibitors exhibit good in vitro antibacterial activity against a variety of susceptible and resistant Gram-positive organisms. The moiety at the 2-position of the benzimidazole was extensively modified. In addition, the regioisomeric benzoxazoles, heterocyclic replacements for the benzimidazole, have been synthesized and their activity against the TCS evaluated.Entities:
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Year: 2001 PMID： 11412977 DOI： 10.1016/s0960-894x(01)00024-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823