| Literature DB >> 11411524 |
Y Takeuchi1, M Koike, K Azuma, H Nishioka, H Abe, H S Kim, Y Wataya, T Harayama.
Abstract
The regioisomers (2a,b) of the piperidine ring of febrifugine (1a) and isofebrifugine (1b) were synthesized from 4-allyl-3-piperidone (5). Reduction of 5 afforded a mixture of the trans and cis alcohols (6a,b) without diastereoselectivity; this result differentiated it from the reduction of 2-allyl-3-piperidone (14). The antimalarial activity of 2a,b and related compounds was tested.Entities:
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Year: 2001 PMID： 11411524 DOI： 10.1248/cpb.49.721
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645