[Pathogenesis and guidelines for therapy of atopic dermatitis].

Atopic dermatitis (AD) is regarded as one of type 2 helper T cell (Th2)-mediated diseases. However, our data by in situ hybridization elucidated mRNA expressions of both Th1 and Th2 cyotokine in the lesions of AD. Some work revealed a decrease of Th1 mRNA without a change of Th2 mRNA after remission by therapy. Th1 may closely relate to skin lesions of AD. Our work showed a IL-4 and IL-5 production and a elevated expression of high affinity IgE receptor by eosinophils in the lesions of AD. Uptake of allergens may be mediated by the receptor and may lead to a release of cytokines. A guideline for therapy for AD, supported by a Ministry of Health and Welfare in Japan, is published in 1999. In this paper, the guideline was outlined.