BACKGROUND: Fanconi anaemia is a rare disease associated with cellular sensitivity to chemicals (e.g. mitomycin C and diepoxybutane); variable but mild cellular radiosensitivity has also been reported. MATERIALS AND METHODS: A 32-year-old patient with Fanconi anaemia and tonsillar carcinoma, treated by radiotherapy, was found to exhibit profound clinical radiosensitivity. Confluent, ulcerating oropharyngeal mucositis developed after a conventionally fractionated dose of 34Gy and healing was incomplete by 2 months after cessation of therapy. RESULTS: Cellular radiosensitivity assays and RPLD studies from this patient did not suggest any major detectable radiosensitivity. CONCLUSION: There is a discrepancy between the observed clinical radiosensitivity and the usual "predictive" radiosensitivity assays in this patient with Fanconi anaemia.
BACKGROUND:Fanconi anaemia is a rare disease associated with cellular sensitivity to chemicals (e.g. mitomycin C and diepoxybutane); variable but mild cellular radiosensitivity has also been reported. MATERIALS AND METHODS: A 32-year-old patient with Fanconi anaemia and tonsillar carcinoma, treated by radiotherapy, was found to exhibit profound clinical radiosensitivity. Confluent, ulcerating oropharyngeal mucositis developed after a conventionally fractionated dose of 34Gy and healing was incomplete by 2 months after cessation of therapy. RESULTS: Cellular radiosensitivity assays and RPLD studies from this patient did not suggest any major detectable radiosensitivity. CONCLUSION: There is a discrepancy between the observed clinical radiosensitivity and the usual "predictive" radiosensitivity assays in this patient with Fanconi anaemia.
Authors: Andrew C Birkeland; Arleen D Auerbach; Erica Sanborn; Bhupesh Parashar; William I Kuhel; Settara C Chandrasekharappa; Agata Smogorzewska; David I Kutler Journal: Arch Otolaryngol Head Neck Surg Date: 2011-09
Authors: Igor Sirák; Zuzana Šinkorová; Mária Šenkeříková; Jiří Špaček; Jan Laco; Hana Vošmiková; Stanislav John; Jiří Petera Journal: Rep Pract Oncol Radiother Date: 2014-12-05
Authors: Verena M Kuhnert; Lisa A Kachnic; Li Li; Martin Purschke; Liliana Gheorghiu; Richard Lee; Kathryn D Held; Henning Willers Journal: Int J Radiat Biol Date: 2009-06 Impact factor: 2.694
Authors: E E Hoskins; T A Morris; J M Higginbotham; N Spardy; E Cha; P Kelly; D A Williams; K A Wikenheiser-Brokamp; S Duensing; S I Wells Journal: Oncogene Date: 2008-11-17 Impact factor: 9.867