Different regulation of RGS2 mRNA by haloperidol and clozapine.

Expression of RGS2 mRNA was transiently up-regulated in rat striatum (25% in the medial part and 50% in the lateral part), in contrast to cingulate cortex and lateral septum, 30 min after acute treatment with haloperidol (2 mg/kg, i.p.). This effect disappeared 24 hours post-drug treatment, similar to the acute and strong up-regulation (700% at 30 min) of c-fos mRNA. RGS3, 5, 6, 8 or 9 mRNAs were not affected. Clozapine (20 mg/kg, i.p.) at an approximately equivalent dose of D2 receptor occupancy in the striatum did not significantly affect RGS and c-fos mRNAs levels. We suggest that RGS2 mRNA expression may be differently up-regulated in a region-specific manner by antipsychotics.