Literature DB >> 11409725

Selective up-regulation of 5-HT(1B/1D) receptors during organ culture of cerebral arteries.

N L Hoel1, J Hansen-Schwartz, L Edvinsson.   

Abstract

5-Hydroxytryptamine (5-HT) is thought to be involved in migraine headache and the pathophysiology of cerebrovascular diseases. Previous data show that organ culture induces a phenotypic change in cerebral vessels. Therefore we investigated if these changes also applied for the vasoconstrictive 5-HT receptors. Rat cerebral arteries express 5-HT2 receptors. Using organ culture we observed a phenotypic change with a selective up-regulation of 5-HT(1B/1D) receptors. This was revealed by an increased sensitivity to the selective 5-HT(1B/1D) agonist 5-CT after organ culture (pEC50(fresh) 5.6+/-0.2 and pEC50(cultured) 6.8+/-0.4). The response was inhibited by the 5-HT(1B/1D) selective antagonist GR55562 (pEC50(fresh) 5.1+/-0.2 and pEC50(cultured) 6.0+/-0.3). The organ model might mimic the phenotypic changes during cerebrovascular diseases.

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Year:  2001        PMID： 11409725     DOI： 10.1097/00001756-200106130-00019

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  12 in total

Review 1.  Vascular plasticity in cerebrovascular disorders.

Authors:  Lars I H Edvinsson; Gro Klitgaard Povlsen
Journal:  J Cereb Blood Flow Metab       Date:  2011-05-11       Impact factor: 6.200

2.  Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway.

Authors:  Hilda Ahnstedt; Hans Säveland; Ola Nilsson; Lars Edvinsson
Journal:  BMC Neurosci       Date:  2011-01-11       Impact factor: 3.288

3.  Protein kinase mediated upregulation of endothelin A, endothelin B and 5-hydroxytryptamine 1B/1D receptors during organ culture in rat basilar artery.

Authors:  Jacob Hansen-Schwartz; Carl-Lennart Svensson; Cang-Bao Xu; Lars Edvinsson
Journal:  Br J Pharmacol       Date:  2002-09       Impact factor: 8.739

4.  Mechanisms involved in the early increase of serotonin contraction evoked by endotoxin in rat middle cerebral arteries.

Authors:  Raquel Hernanz; Maria J Alonso; Ana M Briones; Elisabet Vila; Ulf Simonsen; Mercedes Salaices
Journal:  Br J Pharmacol       Date:  2003-10       Impact factor: 8.739

5.  In vivo experimental stroke and in vitro organ culture induce similar changes in vasoconstrictor receptors and intracellular calcium handling in rat cerebral arteries.

Authors:  Gro Klitgaard Povlsen; Roya Waldsee; Hilda Ahnstedt; Kim Anker Kristiansen; Flemming Fryd Johansen; Lars Edvinsson
Journal:  Exp Brain Res       Date:  2012-05-15       Impact factor: 1.972

6.  Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage.

Authors:  Saema Ansar; Aida Maddahi; Lars Edvinsson
Journal:  BMC Neurosci       Date:  2011-10-27       Impact factor: 3.288

7.  Organ culture: a new model for vascular endothelium dysfunction.

Authors:  Rikard Alm; Lars Edvinsson; Malin Malmsjö
Journal:  BMC Cardiovasc Disord       Date:  2002-05-05       Impact factor: 2.298

Review 8.  G-Protein-Coupled Receptors and Ischemic Stroke: a Focus on Molecular Function and Therapeutic Potential.

Authors:  Zeinab Vahidinia; Mohammad Taghi Joghataei; Cordian Beyer; Mohammad Karimian; Abolfazl Azami Tameh
Journal:  Mol Neurobiol       Date:  2021-06-12       Impact factor: 5.590

9.  Early events triggering delayed vasoconstrictor receptor upregulation and cerebral ischemia after subarachnoid hemorrhage.

Authors:  Gro Klitgaard Povlsen; Sara Ellinor Johansson; Carl Christian Larsen; Ajoy Kumar Samraj; Lars Edvinsson
Journal:  BMC Neurosci       Date:  2013-03-15       Impact factor: 3.288

10.  Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia.

Authors:  Sara Johansson; Gro Klitgaard Povlsen; Lars Edvinsson
Journal:  PLoS One       Date:  2012-07-27       Impact factor: 3.240
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