Literature DB >> 11408928

Immortalization of human esophageal keratinocytes by E6 and E7 of human papillomavirus type 16.

H Sashiyama1, Y Shino, Y Kawamata, Y Tomita, N Ogawa, H Shimada, S Kobayashi, T Asano, T Ochiai, H Shirasawa.   

Abstract

Transduction of human papillomavirus type 16 (HPV16) E6/E7 into primary culture of human esophageal keratinocytes using a recombinant adenovirus prolonged the life-span, while untreated cells senesced within 14-16 population doublings (PDLs). Up-regulation of telomerase activity and acquisition of serum-resistant growth were observed in the esophageal keratinocytes with extended life-span between 50 and 100 PDLs, and drastically increased after 100 PDLs. A keratinocyte sample with a polymorphism of Pro/Pro at codon 72 of p53 showed resistance to HPV16 E6/E7-induced life-span-extension and immortalization, in contrast to others with p53 polymorphisms of Arg/Arg or Arg/Pro, which did not. The high efficiency of E6/E7-induction by adenovirus vector also revealed the M1 and M2 stages of keratinocyte immortalization first described in this report.

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Year:  2001        PMID： 11408928     DOI： 10.3892/ijo.19.1.97

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  10 in total

1.  Distinct patterns of gene expression induced by viral oncogenes in human embryonic brain cells.

Authors:  Piruz Nahreini; Cynthia Andreatta; Bipin Kumar; Amy Hanson; Judith Edwards-Prasad; Curt R Freed; Kedar N Prasad
Journal:  Cell Mol Neurobiol       Date:  2003-02       Impact factor: 5.046

2.  Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile.

Authors:  Andres Castillo; Francisco Aguayo; Chihaya Koriyama; Miyerlandi Torres; Edwin Carrascal; Alejandro Corvalan; Juan-P Roblero; Cecilia Naquira; Mariana Palma; Claudia Backhouse; Jorge Argandona; Tetsuhiko Itoh; Karem Shuyama; Yoshito Eizuru; Suminori Akiba
Journal:  World J Gastroenterol       Date:  2006-10-14       Impact factor: 5.742

3.  HIF-1α stimulates the progression of oesophageal squamous cell carcinoma by activating the Wnt/β-catenin signalling pathway.

Authors:  Kang Tang; Takeshi Toyozumi; Kentaro Murakami; Haruhito Sakata; Masayuki Kano; Satoshi Endo; Yasunori Matsumoto; Hiroshi Suito; Masahiko Takahashi; Nobufumi Sekino; Ryota Otsuka; Kazuya Kinoshita; Soichiro Hirasawa; Jie Hu; Masaya Uesato; Koichi Hayano; Hisahiro Matsubara
Journal:  Br J Cancer       Date:  2022-04-28       Impact factor: 9.075

4.  Viral load of HPV 16/18 in esophageal squamous cell carcinoma in three ethnic groups living in Xinjiang Autonomous Region, China.

Authors:  Tao Liu; Qing Liu; Meng Liang; Shutao Zheng; Xiu Ling Li; Xiaomei Lu; Ilyar Sheyhidin
Journal:  Mol Biol Rep       Date:  2012-12-06       Impact factor: 2.316

Review 5.  HPV infections and oesophageal cancer.

Authors:  K J Syrjänen
Journal:  J Clin Pathol       Date:  2002-10       Impact factor: 3.411

Review 6.  Regulation of the Wnt/β-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.

Authors:  Jesus Omar Muñoz Bello; Leslie Olmedo Nieva; Adriana Contreras Paredes; Alma Mariana Fuentes Gonzalez; Leticia Rocha Zavaleta; Marcela Lizano
Journal:  Viruses       Date:  2015-08-19       Impact factor: 5.048

7.  Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.

Authors:  Mitsuteru Natsuizaka; Kelly A Whelan; Shingo Kagawa; Koji Tanaka; Veronique Giroux; Prasanna M Chandramouleeswaran; Apple Long; Varun Sahu; Douglas S Darling; Jianwen Que; Yizeng Yang; Jonathan P Katz; E Paul Wileyto; Devraj Basu; Yoshiaki Kita; Shoji Natsugoe; Seiji Naganuma; Andres J Klein-Szanto; J Alan Diehl; Adam J Bass; Kwok-Kin Wong; Anil K Rustgi; Hiroshi Nakagawa
Journal:  Nat Commun       Date:  2017-11-24       Impact factor: 14.919

Review 8.  The Drivers, Mechanisms, and Consequences of Genome Instability in HPV-Driven Cancers.

Authors:  Vanessa L Porter; Marco A Marra
Journal:  Cancers (Basel)       Date:  2022-09-23       Impact factor: 6.575

9.  Sequence variation in the E2-binding domain of HPV16 and biological function evaluation in Tunisian cervical cancers.

Authors:  Saloua Kahla; Lotfi Kochbati; Samia Hammami; Mohamed Badis Chanoufi; Mongi Maalej; Ridha Oueslati
Journal:  Biomed Res Int       Date:  2014-06-17       Impact factor: 3.411

10.  Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities.

Authors:  S Kagawa; M Natsuizaka; K A Whelan; N Facompre; S Naganuma; S Ohashi; H Kinugasa; A M Egloff; D Basu; P A Gimotty; A J Klein-Szanto; A J Bass; K-K Wong; J A Diehl; A K Rustgi; H Nakagawa
Journal:  Oncogene       Date:  2014-06-16       Impact factor: 9.867
  10 in total

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