Immunogenicity of lipid-conjugated protein in the intestine.

Acylation of human serum albumin increases its ability to stimulate antibody formation in rats. This can be shown not only when the antigen was given intramuscularly but also when administered by injection into the lumen of the gut. A tendency of the modified molecules to attach to cells and to aggregate, increased anti-complementary activity, and reduced drainage through the lymphatics, have been demonstrated. The relationship of these features to the increased immunogenicity is discussed.