| Literature DB >> 11408058 |
Y Kiyozuka1, H Nakagawa, Y Uemura, H Senzaki, A Yamamoto, T Noguchi, H Mizuta, K Nakanishi, S Nakano, A Tsubura.
Abstract
Two cell lines (Nara-H and Nara-F) with different phenotypes were established from a myxoid MFH of the uterus. In vitro, Nara-F grew in sheets showing a storiform arrangement and Nara-H in raised colonies. Although tumors generated in nude mice shared similar morphological features of abundant myxoid tumor in Nara-H and -F, the pleomorphic component was conspicuous in Nara-F. Both cell lines produced hyaluronic-acid but CD44 was expressed only in Nara-H. Estrogen receptor alpha (ER alpha) and progesterone receptor (PgR) were detected in Nara-H. Nara-F was positive for ER beta and PgR. Among hormonal agents, the response to the anti-estrogen tamoxifen was more sensitive than progesterone agents. This report illustrates the characteristics of these newly established cell lines, and presents the possibility of an adjuvant hormonal therapy for MFH.Entities:
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Year: 2001 PMID： 11408058 DOI： 10.1016/s0165-4608(00)00413-1
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608